Studying gold nanoparticle degradation during laser ablation-single particle-inductively coupled plasma mass spectrometry analysis
Nanoparticle (NP) analysis performed by laser ablation-single particle-inductively coupled plasma mass spectrometry (LA-sp-ICPMS) has recently allowed for multimodal insights to be gained about NPs in biological tissues. In our previous work, NP localizing, sizing and counting, as well as differenti...
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| Veröffentlicht in: | Journal of analytical atomic spectrometry 2021-09, Vol.36 (9), p.1879-1883 |
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| container_title | Journal of analytical atomic spectrometry |
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| creator | Metarapi, Dino van Elteren, Johannes T Šala, Martin |
| description | Nanoparticle (NP) analysis performed by laser ablation-single particle-inductively coupled plasma mass spectrometry (LA-sp-ICPMS) has recently allowed for multimodal insights to be gained about NPs in biological tissues. In our previous work, NP localizing, sizing and counting, as well as differentiating between the metal NP signal and its ionic form were achieved. In all of these, a low laser fluence ( |
| doi_str_mv | 10.1039/d1ja00150g |
| format | Article |
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−2
) was used, as it was observed that higher laser fluences can induce NP degradation, thus invalidating the results. This work is an in-depth study of gold NP (AuNP) degradation upon laser ablation, and provides guidelines for selection of the optimal laser fluence associated with NP analysis in gelatine as a matrix which mimics biological tissues. AuNPs of known size and with a narrow size distribution (CV < 5%) were used to keep track of the measured NP size with changing laser fluence. In addition, optical profilometry was utilized to measure the amount of material ablated as a function of the laser fluence, and provide a more accurate estimation of the NP degradation.
This work is a study of gold nanoparticle (NP) degradation upon laser ablation and provides guidelines for the optimal laser fluence for NP analysis by laser ablation single particle inductively coupled plasma mass spectrometry (LA-sp-ICPMS).</description><identifier>ISSN: 0267-9477</identifier><identifier>EISSN: 1364-5544</identifier><identifier>DOI: 10.1039/d1ja00150g</identifier><language>eng</language><publisher>London: Royal Society of Chemistry</publisher><subject>Ablation ; Ablative materials ; Degradation ; Fluence ; Gold ; Inductively coupled plasma mass spectrometry ; Laser ablation ; Lasers ; Mass spectrometry ; Nanoparticles ; Particle size distribution ; Scientific imaging ; Spectroscopy ; Tissues</subject><ispartof>Journal of analytical atomic spectrometry, 2021-09, Vol.36 (9), p.1879-1883</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-8e76e5bb7043254ae75ea71b2f8b0c6dcf4acf0d74ed7aa5fc62e6f3327629b83</citedby><cites>FETCH-LOGICAL-c277t-8e76e5bb7043254ae75ea71b2f8b0c6dcf4acf0d74ed7aa5fc62e6f3327629b83</cites><orcidid>0000-0003-2237-7821 ; 0000-0003-0524-0487 ; 0000-0001-7845-860X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Metarapi, Dino</creatorcontrib><creatorcontrib>van Elteren, Johannes T</creatorcontrib><creatorcontrib>Šala, Martin</creatorcontrib><title>Studying gold nanoparticle degradation during laser ablation-single particle-inductively coupled plasma mass spectrometry analysis</title><title>Journal of analytical atomic spectrometry</title><description>Nanoparticle (NP) analysis performed by laser ablation-single particle-inductively coupled plasma mass spectrometry (LA-sp-ICPMS) has recently allowed for multimodal insights to be gained about NPs in biological tissues. In our previous work, NP localizing, sizing and counting, as well as differentiating between the metal NP signal and its ionic form were achieved. In all of these, a low laser fluence (<1 J cm
−2
) was used, as it was observed that higher laser fluences can induce NP degradation, thus invalidating the results. This work is an in-depth study of gold NP (AuNP) degradation upon laser ablation, and provides guidelines for selection of the optimal laser fluence associated with NP analysis in gelatine as a matrix which mimics biological tissues. AuNPs of known size and with a narrow size distribution (CV < 5%) were used to keep track of the measured NP size with changing laser fluence. In addition, optical profilometry was utilized to measure the amount of material ablated as a function of the laser fluence, and provide a more accurate estimation of the NP degradation.
This work is a study of gold nanoparticle (NP) degradation upon laser ablation and provides guidelines for the optimal laser fluence for NP analysis by laser ablation single particle inductively coupled plasma mass spectrometry (LA-sp-ICPMS).</description><subject>Ablation</subject><subject>Ablative materials</subject><subject>Degradation</subject><subject>Fluence</subject><subject>Gold</subject><subject>Inductively coupled plasma mass spectrometry</subject><subject>Laser ablation</subject><subject>Lasers</subject><subject>Mass spectrometry</subject><subject>Nanoparticles</subject><subject>Particle size distribution</subject><subject>Scientific imaging</subject><subject>Spectroscopy</subject><subject>Tissues</subject><issn>0267-9477</issn><issn>1364-5544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpFkUtLxDAUhYMoOI5u3AsBd0I1SfNol4OPURlwoa7LbZKWDp2mJqnQrb_czoyPu7lw-M7lcg5C55RcU5LmN4augRAqSH2AZjSVPBGC80M0I0yqJOdKHaOTENaEEC6YmKGv1ziYselqXLvW4A4614OPjW4tNrb2YCA2rsNm8FuohWA9hrLdqUmYtAn8dSRNZwYdm0_bjli7oW-twf3k2QDeQAg49FZH7zY2-hFDB-0YmnCKjipogz372XP0_nD_dvuYrF6WT7eLVaKZUjHJrJJWlKUiPGWCg1XCgqIlq7KSaGl0xUFXxChujQIQlZbMyipNmZIsL7N0ji73d3vvPgYbYrF2g5-eCAUTUuU8m2airvaU9i4Eb6ui980G_FhQUmwzLu7o82KX8XKCL_awD_qP--8g_QZVUn0s</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Metarapi, Dino</creator><creator>van Elteren, Johannes T</creator><creator>Šala, Martin</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-2237-7821</orcidid><orcidid>https://orcid.org/0000-0003-0524-0487</orcidid><orcidid>https://orcid.org/0000-0001-7845-860X</orcidid></search><sort><creationdate>20210901</creationdate><title>Studying gold nanoparticle degradation during laser ablation-single particle-inductively coupled plasma mass spectrometry analysis</title><author>Metarapi, Dino ; van Elteren, Johannes T ; Šala, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-8e76e5bb7043254ae75ea71b2f8b0c6dcf4acf0d74ed7aa5fc62e6f3327629b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Ablative materials</topic><topic>Degradation</topic><topic>Fluence</topic><topic>Gold</topic><topic>Inductively coupled plasma mass spectrometry</topic><topic>Laser ablation</topic><topic>Lasers</topic><topic>Mass spectrometry</topic><topic>Nanoparticles</topic><topic>Particle size distribution</topic><topic>Scientific imaging</topic><topic>Spectroscopy</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metarapi, Dino</creatorcontrib><creatorcontrib>van Elteren, Johannes T</creatorcontrib><creatorcontrib>Šala, Martin</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of analytical atomic spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metarapi, Dino</au><au>van Elteren, Johannes T</au><au>Šala, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studying gold nanoparticle degradation during laser ablation-single particle-inductively coupled plasma mass spectrometry analysis</atitle><jtitle>Journal of analytical atomic spectrometry</jtitle><date>2021-09-01</date><risdate>2021</risdate><volume>36</volume><issue>9</issue><spage>1879</spage><epage>1883</epage><pages>1879-1883</pages><issn>0267-9477</issn><eissn>1364-5544</eissn><abstract>Nanoparticle (NP) analysis performed by laser ablation-single particle-inductively coupled plasma mass spectrometry (LA-sp-ICPMS) has recently allowed for multimodal insights to be gained about NPs in biological tissues. In our previous work, NP localizing, sizing and counting, as well as differentiating between the metal NP signal and its ionic form were achieved. In all of these, a low laser fluence (<1 J cm
−2
) was used, as it was observed that higher laser fluences can induce NP degradation, thus invalidating the results. This work is an in-depth study of gold NP (AuNP) degradation upon laser ablation, and provides guidelines for selection of the optimal laser fluence associated with NP analysis in gelatine as a matrix which mimics biological tissues. AuNPs of known size and with a narrow size distribution (CV < 5%) were used to keep track of the measured NP size with changing laser fluence. In addition, optical profilometry was utilized to measure the amount of material ablated as a function of the laser fluence, and provide a more accurate estimation of the NP degradation.
This work is a study of gold nanoparticle (NP) degradation upon laser ablation and provides guidelines for the optimal laser fluence for NP analysis by laser ablation single particle inductively coupled plasma mass spectrometry (LA-sp-ICPMS).</abstract><cop>London</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d1ja00150g</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-2237-7821</orcidid><orcidid>https://orcid.org/0000-0003-0524-0487</orcidid><orcidid>https://orcid.org/0000-0001-7845-860X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0267-9477 |
| ispartof | Journal of analytical atomic spectrometry, 2021-09, Vol.36 (9), p.1879-1883 |
| issn | 0267-9477 1364-5544 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Ablation Ablative materials Degradation Fluence Gold Inductively coupled plasma mass spectrometry Laser ablation Lasers Mass spectrometry Nanoparticles Particle size distribution Scientific imaging Spectroscopy Tissues |
| title | Studying gold nanoparticle degradation during laser ablation-single particle-inductively coupled plasma mass spectrometry analysis |
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