The anti-fatigue effect of the oligopeptide modulation of the AMPK/PGC-1α pathway in mice
The Auxis thazard oligopeptide (ATO) was obtained by papain digestion and ultrafiltration membrane separation, and its anti-fatigue effects and mechanisms were evaluated using animal experiments on Kunming mice. Compared with the negative control group, the ATO extended the time to exhaustion in mic...
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| Veröffentlicht in: | Food & function 2022-02, Vol.13 (3), p.1641-165 |
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| creator | Qu, Yushan Ji, Hongwu Song, Wenkui Peng, Shuo Zhan, Suhong Wei, Liuyi Chen, Ming Zhang, Di Liu, Shucheng |
| description | The
Auxis thazard
oligopeptide (ATO) was obtained by papain digestion and ultrafiltration membrane separation, and its anti-fatigue effects and mechanisms were evaluated using animal experiments on Kunming mice. Compared with the negative control group, the ATO extended the time to exhaustion in mice in a forced swim test by 0.81-1.62 times. Liver glycogen levels were significantly increased by 0.6-1.63 times and muscle glycogen levels were increased by 9.52-10.02%; the levels of lactic acid (16.46-17.21%) and urea nitrogen (34.88-41.91%) decreased. The ATO also increased antioxidant activity, reduced malondialdehyde levels (18.00-35.79%) in the liver and myocardium, and increased the gene and protein expression of AMPK and PGC-1α in fatigued mice. These results indicate that the ATO exerts an anti-fatigue effect
via
improving energy metabolism and decreasing oxidative stress.
The anti-fatigue effect of the ATO has been confirmed for the first time and its mechanism was revealed from the modulation of the oxidative stress and AMPK/PGC-1α pathway in mice. |
| doi_str_mv | 10.1039/d1fo03320d |
| format | Article |
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Auxis thazard
oligopeptide (ATO) was obtained by papain digestion and ultrafiltration membrane separation, and its anti-fatigue effects and mechanisms were evaluated using animal experiments on Kunming mice. Compared with the negative control group, the ATO extended the time to exhaustion in mice in a forced swim test by 0.81-1.62 times. Liver glycogen levels were significantly increased by 0.6-1.63 times and muscle glycogen levels were increased by 9.52-10.02%; the levels of lactic acid (16.46-17.21%) and urea nitrogen (34.88-41.91%) decreased. The ATO also increased antioxidant activity, reduced malondialdehyde levels (18.00-35.79%) in the liver and myocardium, and increased the gene and protein expression of AMPK and PGC-1α in fatigued mice. These results indicate that the ATO exerts an anti-fatigue effect
via
improving energy metabolism and decreasing oxidative stress.
The anti-fatigue effect of the ATO has been confirmed for the first time and its mechanism was revealed from the modulation of the oxidative stress and AMPK/PGC-1α pathway in mice.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo03320d</identifier><ispartof>Food & function, 2022-02, Vol.13 (3), p.1641-165</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Qu, Yushan</creatorcontrib><creatorcontrib>Ji, Hongwu</creatorcontrib><creatorcontrib>Song, Wenkui</creatorcontrib><creatorcontrib>Peng, Shuo</creatorcontrib><creatorcontrib>Zhan, Suhong</creatorcontrib><creatorcontrib>Wei, Liuyi</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Liu, Shucheng</creatorcontrib><title>The anti-fatigue effect of the oligopeptide modulation of the AMPK/PGC-1α pathway in mice</title><title>Food & function</title><description>The
Auxis thazard
oligopeptide (ATO) was obtained by papain digestion and ultrafiltration membrane separation, and its anti-fatigue effects and mechanisms were evaluated using animal experiments on Kunming mice. Compared with the negative control group, the ATO extended the time to exhaustion in mice in a forced swim test by 0.81-1.62 times. Liver glycogen levels were significantly increased by 0.6-1.63 times and muscle glycogen levels were increased by 9.52-10.02%; the levels of lactic acid (16.46-17.21%) and urea nitrogen (34.88-41.91%) decreased. The ATO also increased antioxidant activity, reduced malondialdehyde levels (18.00-35.79%) in the liver and myocardium, and increased the gene and protein expression of AMPK and PGC-1α in fatigued mice. These results indicate that the ATO exerts an anti-fatigue effect
via
improving energy metabolism and decreasing oxidative stress.
The anti-fatigue effect of the ATO has been confirmed for the first time and its mechanism was revealed from the modulation of the oxidative stress and AMPK/PGC-1α pathway in mice.</description><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNpjYBAyNNAzNDC21E8xTMs3MDY2MkhhYuA0MjAx0jUzNYhggbFNLM04GHiLi7MMgMDY0tLC0oKTISokI1UhMa8kUzctsSQzvTRVITUtLTW5RCE_TaEEKJWfk5meX5BaUJKZkqqQm59SmgNUlp8Hk3b0DfDWD3B31jU8t1GhILEkozyxUiEzTyE3MzmVh4E1LTGnOJUXSnMzyLq5hjh76BYVJ8cXFGXmJhZVxiPcbExIHgAoOESA</recordid><startdate>20220207</startdate><enddate>20220207</enddate><creator>Qu, Yushan</creator><creator>Ji, Hongwu</creator><creator>Song, Wenkui</creator><creator>Peng, Shuo</creator><creator>Zhan, Suhong</creator><creator>Wei, Liuyi</creator><creator>Chen, Ming</creator><creator>Zhang, Di</creator><creator>Liu, Shucheng</creator><scope/></search><sort><creationdate>20220207</creationdate><title>The anti-fatigue effect of the oligopeptide modulation of the AMPK/PGC-1α pathway in mice</title><author>Qu, Yushan ; Ji, Hongwu ; Song, Wenkui ; Peng, Shuo ; Zhan, Suhong ; Wei, Liuyi ; Chen, Ming ; Zhang, Di ; Liu, Shucheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_d1fo03320d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2022</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Qu, Yushan</creatorcontrib><creatorcontrib>Ji, Hongwu</creatorcontrib><creatorcontrib>Song, Wenkui</creatorcontrib><creatorcontrib>Peng, Shuo</creatorcontrib><creatorcontrib>Zhan, Suhong</creatorcontrib><creatorcontrib>Wei, Liuyi</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Liu, Shucheng</creatorcontrib><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qu, Yushan</au><au>Ji, Hongwu</au><au>Song, Wenkui</au><au>Peng, Shuo</au><au>Zhan, Suhong</au><au>Wei, Liuyi</au><au>Chen, Ming</au><au>Zhang, Di</au><au>Liu, Shucheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The anti-fatigue effect of the oligopeptide modulation of the AMPK/PGC-1α pathway in mice</atitle><jtitle>Food & function</jtitle><date>2022-02-07</date><risdate>2022</risdate><volume>13</volume><issue>3</issue><spage>1641</spage><epage>165</epage><pages>1641-165</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>The
Auxis thazard
oligopeptide (ATO) was obtained by papain digestion and ultrafiltration membrane separation, and its anti-fatigue effects and mechanisms were evaluated using animal experiments on Kunming mice. Compared with the negative control group, the ATO extended the time to exhaustion in mice in a forced swim test by 0.81-1.62 times. Liver glycogen levels were significantly increased by 0.6-1.63 times and muscle glycogen levels were increased by 9.52-10.02%; the levels of lactic acid (16.46-17.21%) and urea nitrogen (34.88-41.91%) decreased. The ATO also increased antioxidant activity, reduced malondialdehyde levels (18.00-35.79%) in the liver and myocardium, and increased the gene and protein expression of AMPK and PGC-1α in fatigued mice. These results indicate that the ATO exerts an anti-fatigue effect
via
improving energy metabolism and decreasing oxidative stress.
The anti-fatigue effect of the ATO has been confirmed for the first time and its mechanism was revealed from the modulation of the oxidative stress and AMPK/PGC-1α pathway in mice.</abstract><doi>10.1039/d1fo03320d</doi><tpages>1</tpages></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008- |
| title | The anti-fatigue effect of the oligopeptide modulation of the AMPK/PGC-1α pathway in mice |
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