The identification and application of a robust ω-transaminase with high tolerance towards substrates and isopropylamine from a directed soil metagenome

ω-Transaminase-mediated asymmetric amination of a ketone substrate has gained significant attention for its immense potential to synthesize chiral amine pharmaceuticals and precursors. However, few of these have been authentically applied in industry due to inherent limitations such as low catalytic...

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Veröffentlicht in:	Catalysis science & technology 2022-04, Vol.12 (7), p.2162-2175
Hauptverfasser:	Xie, Youyu, Wang, Jiguo, Yang, Lin, Wang, Wei, Liu, Qinghai, Wang, Hualei, Wei, Dongzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Ketones Molecular docking Molecular dynamics Optimization Robustness Substrates Transaminases
Online-Zugang:	Volltext
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