Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril

Systemic light chain amyloidosis (AL) causes a malignant pathology associated with the formation of amyloid fibrils that deposit in human organs and tissues, leading to dysfunction and severe morbidity. Amyloid fibril-reactive antibodies have been used to remove amyloid from organs and are effective...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2021-09, Vol.23 (36), p.2634-2644
Hauptverfasser:	Wang, Zhenyu, Huang, Wanying, Liu, Manjun, Kennel, Stephen J, Wall, Jonathan S, Cheng, Xiaolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloidosis Antibodies Binding Chains Grooves Inserts Lysine Molecular docking Molecular dynamics Organs Peptides Structural models
Online-Zugang:	Volltext
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