Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional rol...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-07, Vol.57 (59), p.7236-7239
Hauptverfasser:	Ishikawa, Ryo, Yasuda, Mizuho, Sasaki, Shogo, Ma, Yue, Nagasawa, Kazuo, Tera, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Deoxyribonucleic acid DNA Isomers Ligands Nuclease Stabilization
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creator	Ishikawa, Ryo Yasuda, Mizuho Sasaki, Shogo Ma, Yue Nagasawa, Kazuo Tera, Masayuki
description	The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional role of G4 ligands which inhibit the protein binding to DNA/RNA upon ligand interactions. The ligand binding to the telomeric G-quadruplex enhanced susceptibility to S1 nuclease through the base flipping.
doi_str_mv	10.1039/d1cc03294a
format	Article
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source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Binding Deoxyribonucleic acid DNA Isomers Ligands Nuclease Stabilization
title	Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease
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