Small molecule-induced trinucleotide repeat contractions during DNA synthesis

We demonstrated that a synthetic ligand NA, which selectively binds to a 5′-CAG-3′/5′-CAG-3′ triad, induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. A thorough capillary electrophoresis and sequencing analysis revealed that the d(CAG) 20 te...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-03, Vol.57 (26), p.3235-3238
Hauptverfasser:	Dohno, Chikara, Hagihara, Masaki, Binti Mohd Zaifuddin, Nursakinah, Nihei, Mizuki, Saito, Kaoru, Nakatani, Kazuhiko
Format:	Artikel
Sprache:
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!