Advances and challenges in metallic nanomaterial synthesis and antibacterial applications
Multi-drug resistant bacterial infection has become one of the most serious threats to global public health. The preparation and application of new antibacterial materials are of great significance for solving the infection problem of bacteria, especially multi-drug resistant bacteria. The exception...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-06, Vol.8 (22), p.4764-4777 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Guo, Zengchao Chen, Yun Wang, Yihan Jiang, Hui Wang, Xuemei |
| description | Multi-drug resistant bacterial infection has become one of the most serious threats to global public health. The preparation and application of new antibacterial materials are of great significance for solving the infection problem of bacteria, especially multi-drug resistant bacteria. The exceptional antibacterial effects of metal nanoparticles based on their unique physical and chemical properties make such systems ideal for application as antibacterial drug carriers or self-modified therapeutic agents both
in vitro
and
in vivo
. Metal nanoparticles also have admirable clinical application prospects due to their broad antibacterial spectrum, various antibacterial mechanisms and excellent biocompatibility. Nevertheless, the
in vivo
structural stability, long-term safety and cytotoxicity of the surface modification of metal nanoparticles have yet to be further explored and improved in subsequent studies. Herein, we summarized the research progress concerning the mechanism of metal nanomaterials in terms of antibacterial activity together with the preparation of metal nanostructures. Based on these observations, we also give a brief discussion on the current problems and future developments of metal nanoparticles for antibacterial applications.
Schematic diagram of the antibacterial mechanism of metal nanoparticles. |
| doi_str_mv | 10.1039/d0tb00099j |
| format | Article |
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in vitro
and
in vivo
. Metal nanoparticles also have admirable clinical application prospects due to their broad antibacterial spectrum, various antibacterial mechanisms and excellent biocompatibility. Nevertheless, the
in vivo
structural stability, long-term safety and cytotoxicity of the surface modification of metal nanoparticles have yet to be further explored and improved in subsequent studies. Herein, we summarized the research progress concerning the mechanism of metal nanomaterials in terms of antibacterial activity together with the preparation of metal nanostructures. Based on these observations, we also give a brief discussion on the current problems and future developments of metal nanoparticles for antibacterial applications.
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in vitro
and
in vivo
. Metal nanoparticles also have admirable clinical application prospects due to their broad antibacterial spectrum, various antibacterial mechanisms and excellent biocompatibility. Nevertheless, the
in vivo
structural stability, long-term safety and cytotoxicity of the surface modification of metal nanoparticles have yet to be further explored and improved in subsequent studies. Herein, we summarized the research progress concerning the mechanism of metal nanomaterials in terms of antibacterial activity together with the preparation of metal nanostructures. Based on these observations, we also give a brief discussion on the current problems and future developments of metal nanoparticles for antibacterial applications.
Schematic diagram of the antibacterial mechanism of metal nanoparticles.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antibacterial materials</subject><subject>Bacteria</subject><subject>Bacteria - drug effects</subject><subject>Bacterial diseases</subject><subject>Biocompatibility</subject><subject>Chemical compounds</subject><subject>Chemical properties</subject><subject>Cytotoxicity</subject><subject>Drug carriers</subject><subject>Drug delivery</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial - drug effects</subject><subject>Gold</subject><subject>Infections</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metals</subject><subject>Microbial Sensitivity Tests</subject><subject>Multidrug resistance</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Particle Size</subject><subject>Pharmacology</subject><subject>Public health</subject><subject>Structural stability</subject><subject>Surface Properties</subject><subject>Toxicity</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctPwzAMxiMEYtPYhTuoiBtSwUnTx45jvDWJy5DgVDmPsk5tWpIOaf89gY5x42Rb38-2_JmQYwqXFKLJlYJOAMBkstojQwYxhGlMs_1dDq8DMnZu5RnIaJJF_JAMIsbAY3RI3qbqE43ULkCjArnEqtLm3ZelCWrd-bKUgUHT1NhpW2IVuI3pltqVfQearhQotxq2reexKxvjjshBgZXT420ckZe728XsIZw_3z_OpvNQcuBdGCPqopCSy4mQKhKJTiJgyAtRKMZVHNMUUSLNMsWkTgRHEbECVJrGKMB3jMh5P7e1zcdauy5fNWtr_MqccUrBH5pQT130lLSNc1YXeWvLGu0mp5B_G5nfwOL6x8gnD59uR65FrdUO_bXNAyc9YJ3cqX-f8PrZf3reqiL6ArENhXg</recordid><startdate>20200610</startdate><enddate>20200610</enddate><creator>Guo, Zengchao</creator><creator>Chen, Yun</creator><creator>Wang, Yihan</creator><creator>Jiang, Hui</creator><creator>Wang, Xuemei</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-8044-758X</orcidid><orcidid>https://orcid.org/0000-0001-6882-7774</orcidid></search><sort><creationdate>20200610</creationdate><title>Advances and challenges in metallic nanomaterial synthesis and antibacterial applications</title><author>Guo, Zengchao ; Chen, Yun ; Wang, Yihan ; Jiang, Hui ; Wang, Xuemei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-5aaeffcc4c9bcd3b6e6302a4fbfd24d5517aaca188d2ce6b4ab32f0d775ab0cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antibacterial materials</topic><topic>Bacteria</topic><topic>Bacteria - drug effects</topic><topic>Bacterial diseases</topic><topic>Biocompatibility</topic><topic>Chemical compounds</topic><topic>Chemical properties</topic><topic>Cytotoxicity</topic><topic>Drug carriers</topic><topic>Drug delivery</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial - drug effects</topic><topic>Gold</topic><topic>Infections</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metals</topic><topic>Microbial Sensitivity Tests</topic><topic>Multidrug resistance</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Particle Size</topic><topic>Pharmacology</topic><topic>Public health</topic><topic>Structural stability</topic><topic>Surface Properties</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Zengchao</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><creatorcontrib>Wang, Yihan</creatorcontrib><creatorcontrib>Jiang, Hui</creatorcontrib><creatorcontrib>Wang, Xuemei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of materials chemistry. 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The preparation and application of new antibacterial materials are of great significance for solving the infection problem of bacteria, especially multi-drug resistant bacteria. The exceptional antibacterial effects of metal nanoparticles based on their unique physical and chemical properties make such systems ideal for application as antibacterial drug carriers or self-modified therapeutic agents both
in vitro
and
in vivo
. Metal nanoparticles also have admirable clinical application prospects due to their broad antibacterial spectrum, various antibacterial mechanisms and excellent biocompatibility. Nevertheless, the
in vivo
structural stability, long-term safety and cytotoxicity of the surface modification of metal nanoparticles have yet to be further explored and improved in subsequent studies. Herein, we summarized the research progress concerning the mechanism of metal nanomaterials in terms of antibacterial activity together with the preparation of metal nanostructures. Based on these observations, we also give a brief discussion on the current problems and future developments of metal nanoparticles for antibacterial applications.
Schematic diagram of the antibacterial mechanism of metal nanoparticles.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32207511</pmid><doi>10.1039/d0tb00099j</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-8044-758X</orcidid><orcidid>https://orcid.org/0000-0001-6882-7774</orcidid></addata></record> |
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| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial materials Bacteria Bacteria - drug effects Bacterial diseases Biocompatibility Chemical compounds Chemical properties Cytotoxicity Drug carriers Drug delivery Drug resistance Drug Resistance, Multiple, Bacterial - drug effects Gold Infections Metal Nanoparticles - chemistry Metals Microbial Sensitivity Tests Multidrug resistance Nanomaterials Nanoparticles Nanotechnology Particle Size Pharmacology Public health Structural stability Surface Properties Toxicity |
| title | Advances and challenges in metallic nanomaterial synthesis and antibacterial applications |
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