1-Phenyl--(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl- N -(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are d...
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| Veröffentlicht in: | RSC advances 2020-12, Vol.1 (71), p.43299-43311 |
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| container_issue | 71 |
| container_start_page | 43299 |
| container_title | RSC advances |
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| creator | Hu, Min-Qi Li, Heng Lin, Ying Zhang, Ying Tang, Jie Zuo, Jian-Ping Yu, Li-Fang Tong, Xian-Kun Tang, Wei Yang, Fan |
| description | Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-
N
-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound
4f
with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
A series of novel 1-phenyl-
N
-(benzothiazol-2-yl)methanimine derivatives were synthesized and their
in vitro
inhibitory potencies were evaluated on MERS-S pseudovirus. |
| doi_str_mv | 10.1039/d0ra08442e |
| format | Article |
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N
-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound
4f
with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
A series of novel 1-phenyl-
N
-(benzothiazol-2-yl)methanimine derivatives were synthesized and their
in vitro
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N
-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound
4f
with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
A series of novel 1-phenyl-
N
-(benzothiazol-2-yl)methanimine derivatives were synthesized and their
in vitro
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N
-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound
4f
with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
A series of novel 1-phenyl-
N
-(benzothiazol-2-yl)methanimine derivatives were synthesized and their
in vitro
inhibitory potencies were evaluated on MERS-S pseudovirus.</abstract><doi>10.1039/d0ra08442e</doi><tpages>13</tpages></addata></record> |
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| ispartof | RSC advances, 2020-12, Vol.1 (71), p.43299-43311 |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| title | 1-Phenyl--(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors |
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