Supramolecular nanoparticles constructed from pillar[5]arene-based host-guest complexation with enhanced aggregation-induced emission for imaging-guided drug delivery
Fluorophores with aggregation-induced emission (AIE) characteristics have attracted more and more attention due to their unparalleled advantages in terms of sensitivity and photostability, and have been extensively utilized for disease diagnosis and therapy. However, it remains challenging to restri...
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| Veröffentlicht in: | Materials chemistry frontiers 2021-02, Vol.5 (3), p.1418-1427 |
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| creator | Liu, Dahai Du, Jianshi Qi, Shaolong Li, Mengyao Wang, Jianfeng Liu, Meihan Du, Xianlong Wang, Xinyu Ren, Bichen Wu, Dan Shen, Jie |
| description | Fluorophores with aggregation-induced emission (AIE) characteristics have attracted more and more attention due to their unparalleled advantages in terms of sensitivity and photostability, and have been extensively utilized for disease diagnosis and therapy. However, it remains challenging to restrict the intramolecular rotation of the AIE luminogens (AIEgens) both in solution and aggregated states. Herein, we utilize host-guest chemistry to achieve this meaningful goal by using a carboxylate-modified pillar[5]arene
H
as a supramolecular host and an AIEgen containing a tetraphenylethene core
G
as a guest. The AIE effect of the fluorophore is effectively enhanced upon the formation of an inclusion host-guest complex
H
⊃
G
, and the fluorescence of
H
⊃
G
is much more intensive than that of free
G
. Supramolecular nanoparticles (
SNPs
) with high emission are prepared from
H
⊃
G
using a nanoprecipitation method, which can be used as a fluorescent probe for living cell imaging showing superior photostability against laser excitation. Intriguingly, the formed
SNPs
act as nanocarriers to encapsulate doxorubicin (DOX) to deactivate both the fluorescence of
SNPs
and DOX caused by the energy transfer relay (ETR) effect, which is mediated by Förster resonance energy transfer and aggregation-caused quenching. The release of loaded DOX after cellular internalization interrupts the ETR effect to light up the silenced fluorescence, thus allowing
in situ
visualization of drug release. More importantly, the anticancer efficacy of the loaded drug is greatly maintained using this sophisticated supramolecular system, showing promising potential in imaging-guided drug delivery.
Supramolecular nanoparticles with enhanced aggregation-induced emission are prepared by taking advantage of pillar[5]arene-based host-guest complexation, and are sophisticated nanocarriers for imaging-guided drug delivery. |
| doi_str_mv | 10.1039/d0qm00974a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_rsc_primary_d0qm00974a</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2488101504</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-b03f88d9c2d4856d50b7cd282101493acb4d16d7e712c994bab97813bd375ebb3</originalsourceid><addsrcrecordid>eNpNkUlLxEAQhYMoOIxz8S4EvAnRXhI7OQ7jCiMi6kkk9JZMS9KdqU5c_pC_044j6qmLfl-9quJF0T5GxxjR4kShdYtQwVK-FU0IykiCM8q2_9W70cz7F4QQZoxQhCfR5_3QAW9do-XQcIgtt67j0BvZaB9LZ30Pg-y1iitwbdyZJlBP2TMHbXUiuA_Kyvk-qQft-9DQdo1-571xNn4z_SrWdsWtDBSva9D1t5IYq4bxT7fG-xGtHMSm5bWxdXAyKmgKhjpWujGvGj72op2KN17Pft5p9Hhx_rC4Spa3l9eL-TKRJMd9IhCt8lwVkqg0z05VhgSTiuQEI5wWlEuRKnyqmGaYyKJIBRcFyzEVirJMC0Gn0eHGtwO3Hi8qX9wANowsSZrnwSZDaaCONpQE5z3oquwgbA8fJUblGEV5hu5uvqOYB_hgA4OXv9xfVPQLZtWKrA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2488101504</pqid></control><display><type>article</type><title>Supramolecular nanoparticles constructed from pillar[5]arene-based host-guest complexation with enhanced aggregation-induced emission for imaging-guided drug delivery</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Liu, Dahai ; Du, Jianshi ; Qi, Shaolong ; Li, Mengyao ; Wang, Jianfeng ; Liu, Meihan ; Du, Xianlong ; Wang, Xinyu ; Ren, Bichen ; Wu, Dan ; Shen, Jie</creator><creatorcontrib>Liu, Dahai ; Du, Jianshi ; Qi, Shaolong ; Li, Mengyao ; Wang, Jianfeng ; Liu, Meihan ; Du, Xianlong ; Wang, Xinyu ; Ren, Bichen ; Wu, Dan ; Shen, Jie</creatorcontrib><description>Fluorophores with aggregation-induced emission (AIE) characteristics have attracted more and more attention due to their unparalleled advantages in terms of sensitivity and photostability, and have been extensively utilized for disease diagnosis and therapy. However, it remains challenging to restrict the intramolecular rotation of the AIE luminogens (AIEgens) both in solution and aggregated states. Herein, we utilize host-guest chemistry to achieve this meaningful goal by using a carboxylate-modified pillar[5]arene
H
as a supramolecular host and an AIEgen containing a tetraphenylethene core
G
as a guest. The AIE effect of the fluorophore is effectively enhanced upon the formation of an inclusion host-guest complex
H
⊃
G
, and the fluorescence of
H
⊃
G
is much more intensive than that of free
G
. Supramolecular nanoparticles (
SNPs
) with high emission are prepared from
H
⊃
G
using a nanoprecipitation method, which can be used as a fluorescent probe for living cell imaging showing superior photostability against laser excitation. Intriguingly, the formed
SNPs
act as nanocarriers to encapsulate doxorubicin (DOX) to deactivate both the fluorescence of
SNPs
and DOX caused by the energy transfer relay (ETR) effect, which is mediated by Förster resonance energy transfer and aggregation-caused quenching. The release of loaded DOX after cellular internalization interrupts the ETR effect to light up the silenced fluorescence, thus allowing
in situ
visualization of drug release. More importantly, the anticancer efficacy of the loaded drug is greatly maintained using this sophisticated supramolecular system, showing promising potential in imaging-guided drug delivery.
Supramolecular nanoparticles with enhanced aggregation-induced emission are prepared by taking advantage of pillar[5]arene-based host-guest complexation, and are sophisticated nanocarriers for imaging-guided drug delivery.</description><identifier>ISSN: 2052-1537</identifier><identifier>EISSN: 2052-1537</identifier><identifier>DOI: 10.1039/d0qm00974a</identifier><language>eng</language><publisher>London: Royal Society of Chemistry</publisher><subject>Agglomeration ; Anticancer properties ; Chemical compounds ; Doxorubicin ; Emission ; Energy transfer ; Fluorescent indicators ; Medical imaging ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Supramolecular compounds</subject><ispartof>Materials chemistry frontiers, 2021-02, Vol.5 (3), p.1418-1427</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-b03f88d9c2d4856d50b7cd282101493acb4d16d7e712c994bab97813bd375ebb3</citedby><cites>FETCH-LOGICAL-c281t-b03f88d9c2d4856d50b7cd282101493acb4d16d7e712c994bab97813bd375ebb3</cites><orcidid>0000-0003-4089-4187 ; 0000-0002-8116-0473</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Liu, Dahai</creatorcontrib><creatorcontrib>Du, Jianshi</creatorcontrib><creatorcontrib>Qi, Shaolong</creatorcontrib><creatorcontrib>Li, Mengyao</creatorcontrib><creatorcontrib>Wang, Jianfeng</creatorcontrib><creatorcontrib>Liu, Meihan</creatorcontrib><creatorcontrib>Du, Xianlong</creatorcontrib><creatorcontrib>Wang, Xinyu</creatorcontrib><creatorcontrib>Ren, Bichen</creatorcontrib><creatorcontrib>Wu, Dan</creatorcontrib><creatorcontrib>Shen, Jie</creatorcontrib><title>Supramolecular nanoparticles constructed from pillar[5]arene-based host-guest complexation with enhanced aggregation-induced emission for imaging-guided drug delivery</title><title>Materials chemistry frontiers</title><description>Fluorophores with aggregation-induced emission (AIE) characteristics have attracted more and more attention due to their unparalleled advantages in terms of sensitivity and photostability, and have been extensively utilized for disease diagnosis and therapy. However, it remains challenging to restrict the intramolecular rotation of the AIE luminogens (AIEgens) both in solution and aggregated states. Herein, we utilize host-guest chemistry to achieve this meaningful goal by using a carboxylate-modified pillar[5]arene
H
as a supramolecular host and an AIEgen containing a tetraphenylethene core
G
as a guest. The AIE effect of the fluorophore is effectively enhanced upon the formation of an inclusion host-guest complex
H
⊃
G
, and the fluorescence of
H
⊃
G
is much more intensive than that of free
G
. Supramolecular nanoparticles (
SNPs
) with high emission are prepared from
H
⊃
G
using a nanoprecipitation method, which can be used as a fluorescent probe for living cell imaging showing superior photostability against laser excitation. Intriguingly, the formed
SNPs
act as nanocarriers to encapsulate doxorubicin (DOX) to deactivate both the fluorescence of
SNPs
and DOX caused by the energy transfer relay (ETR) effect, which is mediated by Förster resonance energy transfer and aggregation-caused quenching. The release of loaded DOX after cellular internalization interrupts the ETR effect to light up the silenced fluorescence, thus allowing
in situ
visualization of drug release. More importantly, the anticancer efficacy of the loaded drug is greatly maintained using this sophisticated supramolecular system, showing promising potential in imaging-guided drug delivery.
Supramolecular nanoparticles with enhanced aggregation-induced emission are prepared by taking advantage of pillar[5]arene-based host-guest complexation, and are sophisticated nanocarriers for imaging-guided drug delivery.</description><subject>Agglomeration</subject><subject>Anticancer properties</subject><subject>Chemical compounds</subject><subject>Doxorubicin</subject><subject>Emission</subject><subject>Energy transfer</subject><subject>Fluorescent indicators</subject><subject>Medical imaging</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Supramolecular compounds</subject><issn>2052-1537</issn><issn>2052-1537</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpNkUlLxEAQhYMoOIxz8S4EvAnRXhI7OQ7jCiMi6kkk9JZMS9KdqU5c_pC_044j6qmLfl-9quJF0T5GxxjR4kShdYtQwVK-FU0IykiCM8q2_9W70cz7F4QQZoxQhCfR5_3QAW9do-XQcIgtt67j0BvZaB9LZ30Pg-y1iitwbdyZJlBP2TMHbXUiuA_Kyvk-qQft-9DQdo1-571xNn4z_SrWdsWtDBSva9D1t5IYq4bxT7fG-xGtHMSm5bWxdXAyKmgKhjpWujGvGj72op2KN17Pft5p9Hhx_rC4Spa3l9eL-TKRJMd9IhCt8lwVkqg0z05VhgSTiuQEI5wWlEuRKnyqmGaYyKJIBRcFyzEVirJMC0Gn0eHGtwO3Hi8qX9wANowsSZrnwSZDaaCONpQE5z3oquwgbA8fJUblGEV5hu5uvqOYB_hgA4OXv9xfVPQLZtWKrA</recordid><startdate>20210211</startdate><enddate>20210211</enddate><creator>Liu, Dahai</creator><creator>Du, Jianshi</creator><creator>Qi, Shaolong</creator><creator>Li, Mengyao</creator><creator>Wang, Jianfeng</creator><creator>Liu, Meihan</creator><creator>Du, Xianlong</creator><creator>Wang, Xinyu</creator><creator>Ren, Bichen</creator><creator>Wu, Dan</creator><creator>Shen, Jie</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-4089-4187</orcidid><orcidid>https://orcid.org/0000-0002-8116-0473</orcidid></search><sort><creationdate>20210211</creationdate><title>Supramolecular nanoparticles constructed from pillar[5]arene-based host-guest complexation with enhanced aggregation-induced emission for imaging-guided drug delivery</title><author>Liu, Dahai ; Du, Jianshi ; Qi, Shaolong ; Li, Mengyao ; Wang, Jianfeng ; Liu, Meihan ; Du, Xianlong ; Wang, Xinyu ; Ren, Bichen ; Wu, Dan ; Shen, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-b03f88d9c2d4856d50b7cd282101493acb4d16d7e712c994bab97813bd375ebb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Agglomeration</topic><topic>Anticancer properties</topic><topic>Chemical compounds</topic><topic>Doxorubicin</topic><topic>Emission</topic><topic>Energy transfer</topic><topic>Fluorescent indicators</topic><topic>Medical imaging</topic><topic>Nanoparticles</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Supramolecular compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Dahai</creatorcontrib><creatorcontrib>Du, Jianshi</creatorcontrib><creatorcontrib>Qi, Shaolong</creatorcontrib><creatorcontrib>Li, Mengyao</creatorcontrib><creatorcontrib>Wang, Jianfeng</creatorcontrib><creatorcontrib>Liu, Meihan</creatorcontrib><creatorcontrib>Du, Xianlong</creatorcontrib><creatorcontrib>Wang, Xinyu</creatorcontrib><creatorcontrib>Ren, Bichen</creatorcontrib><creatorcontrib>Wu, Dan</creatorcontrib><creatorcontrib>Shen, Jie</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Materials chemistry frontiers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Dahai</au><au>Du, Jianshi</au><au>Qi, Shaolong</au><au>Li, Mengyao</au><au>Wang, Jianfeng</au><au>Liu, Meihan</au><au>Du, Xianlong</au><au>Wang, Xinyu</au><au>Ren, Bichen</au><au>Wu, Dan</au><au>Shen, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supramolecular nanoparticles constructed from pillar[5]arene-based host-guest complexation with enhanced aggregation-induced emission for imaging-guided drug delivery</atitle><jtitle>Materials chemistry frontiers</jtitle><date>2021-02-11</date><risdate>2021</risdate><volume>5</volume><issue>3</issue><spage>1418</spage><epage>1427</epage><pages>1418-1427</pages><issn>2052-1537</issn><eissn>2052-1537</eissn><abstract>Fluorophores with aggregation-induced emission (AIE) characteristics have attracted more and more attention due to their unparalleled advantages in terms of sensitivity and photostability, and have been extensively utilized for disease diagnosis and therapy. However, it remains challenging to restrict the intramolecular rotation of the AIE luminogens (AIEgens) both in solution and aggregated states. Herein, we utilize host-guest chemistry to achieve this meaningful goal by using a carboxylate-modified pillar[5]arene
H
as a supramolecular host and an AIEgen containing a tetraphenylethene core
G
as a guest. The AIE effect of the fluorophore is effectively enhanced upon the formation of an inclusion host-guest complex
H
⊃
G
, and the fluorescence of
H
⊃
G
is much more intensive than that of free
G
. Supramolecular nanoparticles (
SNPs
) with high emission are prepared from
H
⊃
G
using a nanoprecipitation method, which can be used as a fluorescent probe for living cell imaging showing superior photostability against laser excitation. Intriguingly, the formed
SNPs
act as nanocarriers to encapsulate doxorubicin (DOX) to deactivate both the fluorescence of
SNPs
and DOX caused by the energy transfer relay (ETR) effect, which is mediated by Förster resonance energy transfer and aggregation-caused quenching. The release of loaded DOX after cellular internalization interrupts the ETR effect to light up the silenced fluorescence, thus allowing
in situ
visualization of drug release. More importantly, the anticancer efficacy of the loaded drug is greatly maintained using this sophisticated supramolecular system, showing promising potential in imaging-guided drug delivery.
Supramolecular nanoparticles with enhanced aggregation-induced emission are prepared by taking advantage of pillar[5]arene-based host-guest complexation, and are sophisticated nanocarriers for imaging-guided drug delivery.</abstract><cop>London</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d0qm00974a</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-4089-4187</orcidid><orcidid>https://orcid.org/0000-0002-8116-0473</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Materials chemistry frontiers, 2021-02, Vol.5 (3), p.1418-1427 |
| issn | 2052-1537 2052-1537 |
| language | eng |
| recordid | cdi_rsc_primary_d0qm00974a |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Agglomeration Anticancer properties Chemical compounds Doxorubicin Emission Energy transfer Fluorescent indicators Medical imaging Nanoparticles NMR Nuclear magnetic resonance Supramolecular compounds |
| title | Supramolecular nanoparticles constructed from pillar[5]arene-based host-guest complexation with enhanced aggregation-induced emission for imaging-guided drug delivery |
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