Self-assembly of flavin mononucleotide and a cationic polythiophene in aqueous media: spectroscopic studies and sensing applications

Flavin mononucleotide (FMN) is well known as a cofactor of riboflavin and plays key roles in metabolisms. Self-assembly is one of the most important approaches for maintaining the biological functions of FMN. In this work, a supramolecular self-assembly nano-system driven by non-covalent interaction...

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Veröffentlicht in:Polymer chemistry 2020-06, Vol.11 (22), p.3762-3767
Hauptverfasser: Zhang, Li, Li, Shuanghong, Sun, Yanan, Xiao, Keren, Song, Gang, Lu, Pingan, Yin, Shutao, Huang, Kunlun, Yao, Zhiyi
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container_end_page 3767
container_issue 22
container_start_page 3762
container_title Polymer chemistry
container_volume 11
creator Zhang, Li
Li, Shuanghong
Sun, Yanan
Xiao, Keren
Song, Gang
Lu, Pingan
Yin, Shutao
Huang, Kunlun
Yao, Zhiyi
description Flavin mononucleotide (FMN) is well known as a cofactor of riboflavin and plays key roles in metabolisms. Self-assembly is one of the most important approaches for maintaining the biological functions of FMN. In this work, a supramolecular self-assembly nano-system driven by non-covalent interactions between a water-soluble polythiophene (PMT-1) and FMN is constructed in 100% aqueous solution. In this system, π-stacked nano-aggregates have been formed and the self-assembly process of PMT-1 and FMN has been explored through UV-Vis, fluorescence, and circular dichroism (CD) spectroscopy. The synergistic effect of non-covalent interactions containing electrostatic, hydrophobic and π-π interactions is proposed to account for the formation of PMT-1/FMN nano-superstructures. Furthermore, colorimetric responses of PMT-1 promote the sensing applications of this approach for the rapid and visual detection of FMN. It features wide detection range, fast response, high sensitivity and selectivity. The LOD in buffer and actual sample could be as low as 1.1 and 32 nM, respectively. Self-assembly of flavin mononucleotide and a cationic polythiophene in 100% aqueous media with colorimetric and fluorescence dual responses.
doi_str_mv 10.1039/d0py00403k
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source Royal Society Of Chemistry Journals
subjects Aqueous solutions
Colorimetry
Dichroism
Fluorescence
Polymer chemistry
Polythiophene
Riboflavin
Selectivity
Self-assembly
Superstructures
Synergistic effect
title Self-assembly of flavin mononucleotide and a cationic polythiophene in aqueous media: spectroscopic studies and sensing applications
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