Palladium-catalyzed regioselective synthesis of B(4,5)- or B(4)-substituted -carboranes containing α,β-unsaturated carbonyls

With the help of a carboxylic acid directing group, Pd-catalyzed regioselective synthesis of B(4,5)- or B(4)-substituted o -carboranes containing α,β-unsaturated carbonyls has been reported. The -COOH, removed during the course of the reaction, is responsible for controlling the regioselectivity. The desired products could be obtained in moderate to good yields. B(4,5)- or B(4)-Substituted o -carboranes containing α,β-unsaturated carbonyls are regioselectively synthesized through a Pd-catalyzed decarboxylation cross coupling reaction.