Design, synthesis, biological activities and 3D-QSAR studies of quinazolinone derivatives containing hydrazone structural units

In this study, three series of quinazolinone derivatives containing hydrazone structures were designed and synthesized. Bioactivity assays indicated that these compounds showed good antitumour activities towards human lung cancer cells (A549) and human prostate cancer cells (PC-3) and no apparent to...

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Veröffentlicht in:	New journal of chemistry 2021-03, Vol.45 (1), p.4626-4631
Hauptverfasser:	Shao, Li-Hui, Fan, Si-Li, Meng, Ying-Fen, Gan, Yi-Yuan, Shao, Wu-Bin, Wang, Zhen-Chao, Chen, Dan-Ping, Ouyang, Gui-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Biocompatibility Hydrazones Lead compounds Three dimensional models Toxicity
Online-Zugang:	Volltext
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