Design of a new electrochemical sensing system based on MoS-TiO/reduced graphene oxide nanocomposite for the detection of paracetamol
Herein, we designed a new electrochemical sensor (MoS 2 -TiO 2 /rGO/SPE) based on a molybdenum disulfide (MoS 2 )-titanium dioxide (TiO 2 )/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac)....
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| Veröffentlicht in: | New journal of chemistry 2020-07, Vol.44 (27), p.11759-11767 |
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| container_end_page | 11767 |
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| container_issue | 27 |
| container_start_page | 11759 |
| container_title | New journal of chemistry |
| container_volume | 44 |
| creator | Demir, Neslihan Atacan, Keziban Ozmen, Mustafa Bas, Salih Zeki |
| description | Herein, we designed a new electrochemical sensor (MoS
2
-TiO
2
/rGO/SPE) based on a molybdenum disulfide (MoS
2
)-titanium dioxide (TiO
2
)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This design was optimized by examining the effect of the rGO : MoS
2
-TiO
2
ratio, MoS
2
-TiO
2
/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS
2
-TiO
2
/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM
−1
. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS
2
-TiO
2
/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS
2
-TiO
2
/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids.
Synthetic route for the MoS
2
-TiO
2
/rGO nanocomposite and the electrode reaction for paracetamol. |
| doi_str_mv | 10.1039/d0nj02298e |
| format | Article |
| fullrecord | <record><control><sourceid>rsc</sourceid><recordid>TN_cdi_rsc_primary_d0nj02298e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>d0nj02298e</sourcerecordid><originalsourceid>FETCH-rsc_primary_d0nj02298e3</originalsourceid><addsrcrecordid>eNqFj09LxDAUxIMouO568S48P0DdpK3Vnv3DXsSDey_Z5LXN0uSFvIjuB_B7W0TwpqcZZuA3jBAXSl4rWbVrK8NelmV7h0dioaqmLdqyUcezV3VdyJu6ORVnzHsplbpt1EJ8PiC7IQD1oCHgO-CEJicyI3pn9ASMgV0YgA-c0cNOM1qgAM_0WmzdyzqhfTNzNCQdRwwI9OEsQtCBDPlI7DJCTwnyiGAxz3RH33tRJ20wa0_TSpz0emI8_9GluHx63N5visSmi8l5nQ7d77dqKa7-6rto--o_xhd-YGAw</addsrcrecordid><sourcetype>Enrichment Source</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Design of a new electrochemical sensing system based on MoS-TiO/reduced graphene oxide nanocomposite for the detection of paracetamol</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Demir, Neslihan ; Atacan, Keziban ; Ozmen, Mustafa ; Bas, Salih Zeki</creator><creatorcontrib>Demir, Neslihan ; Atacan, Keziban ; Ozmen, Mustafa ; Bas, Salih Zeki</creatorcontrib><description>Herein, we designed a new electrochemical sensor (MoS
2
-TiO
2
/rGO/SPE) based on a molybdenum disulfide (MoS
2
)-titanium dioxide (TiO
2
)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This design was optimized by examining the effect of the rGO : MoS
2
-TiO
2
ratio, MoS
2
-TiO
2
/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS
2
-TiO
2
/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM
−1
. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS
2
-TiO
2
/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS
2
-TiO
2
/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids.
Synthetic route for the MoS
2
-TiO
2
/rGO nanocomposite and the electrode reaction for paracetamol.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/d0nj02298e</identifier><language>eng</language><ispartof>New journal of chemistry, 2020-07, Vol.44 (27), p.11759-11767</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Demir, Neslihan</creatorcontrib><creatorcontrib>Atacan, Keziban</creatorcontrib><creatorcontrib>Ozmen, Mustafa</creatorcontrib><creatorcontrib>Bas, Salih Zeki</creatorcontrib><title>Design of a new electrochemical sensing system based on MoS-TiO/reduced graphene oxide nanocomposite for the detection of paracetamol</title><title>New journal of chemistry</title><description>Herein, we designed a new electrochemical sensor (MoS
2
-TiO
2
/rGO/SPE) based on a molybdenum disulfide (MoS
2
)-titanium dioxide (TiO
2
)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This design was optimized by examining the effect of the rGO : MoS
2
-TiO
2
ratio, MoS
2
-TiO
2
/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS
2
-TiO
2
/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM
−1
. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS
2
-TiO
2
/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS
2
-TiO
2
/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids.
Synthetic route for the MoS
2
-TiO
2
/rGO nanocomposite and the electrode reaction for paracetamol.</description><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFj09LxDAUxIMouO568S48P0DdpK3Vnv3DXsSDey_Z5LXN0uSFvIjuB_B7W0TwpqcZZuA3jBAXSl4rWbVrK8NelmV7h0dioaqmLdqyUcezV3VdyJu6ORVnzHsplbpt1EJ8PiC7IQD1oCHgO-CEJicyI3pn9ASMgV0YgA-c0cNOM1qgAM_0WmzdyzqhfTNzNCQdRwwI9OEsQtCBDPlI7DJCTwnyiGAxz3RH33tRJ20wa0_TSpz0emI8_9GluHx63N5visSmi8l5nQ7d77dqKa7-6rto--o_xhd-YGAw</recordid><startdate>20200713</startdate><enddate>20200713</enddate><creator>Demir, Neslihan</creator><creator>Atacan, Keziban</creator><creator>Ozmen, Mustafa</creator><creator>Bas, Salih Zeki</creator><scope/></search><sort><creationdate>20200713</creationdate><title>Design of a new electrochemical sensing system based on MoS-TiO/reduced graphene oxide nanocomposite for the detection of paracetamol</title><author>Demir, Neslihan ; Atacan, Keziban ; Ozmen, Mustafa ; Bas, Salih Zeki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_d0nj02298e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demir, Neslihan</creatorcontrib><creatorcontrib>Atacan, Keziban</creatorcontrib><creatorcontrib>Ozmen, Mustafa</creatorcontrib><creatorcontrib>Bas, Salih Zeki</creatorcontrib><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demir, Neslihan</au><au>Atacan, Keziban</au><au>Ozmen, Mustafa</au><au>Bas, Salih Zeki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design of a new electrochemical sensing system based on MoS-TiO/reduced graphene oxide nanocomposite for the detection of paracetamol</atitle><jtitle>New journal of chemistry</jtitle><date>2020-07-13</date><risdate>2020</risdate><volume>44</volume><issue>27</issue><spage>11759</spage><epage>11767</epage><pages>11759-11767</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>Herein, we designed a new electrochemical sensor (MoS
2
-TiO
2
/rGO/SPE) based on a molybdenum disulfide (MoS
2
)-titanium dioxide (TiO
2
)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This design was optimized by examining the effect of the rGO : MoS
2
-TiO
2
ratio, MoS
2
-TiO
2
/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS
2
-TiO
2
/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM
−1
. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS
2
-TiO
2
/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS
2
-TiO
2
/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids.
Synthetic route for the MoS
2
-TiO
2
/rGO nanocomposite and the electrode reaction for paracetamol.</abstract><doi>10.1039/d0nj02298e</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2020-07, Vol.44 (27), p.11759-11767 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_rsc_primary_d0nj02298e |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Design of a new electrochemical sensing system based on MoS-TiO/reduced graphene oxide nanocomposite for the detection of paracetamol |
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