Mechanism of zinc ejection by disulfiram in nonstructural protein 5A

Hepatitis C virus (HCV) is a notorious member of the Flaviviridae family of enveloped, positive-strand RNA viruses. Non-structural protein 5A (NS5A) plays a key role in HCV replication and assembly. NS5A is a multi-domain protein which includes an N-terminal amphipathic membrane anchoring alpha heli...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2021-06, Vol.23 (21), p.1224-12215
Hauptverfasser:	Rehman, Ashfaq Ur, Zhen, Guodong, Zhong, Bozitao, Ni, Duan, Li, Jiayi, Nasir, Abdul, Gabr, Moustafa T, Rafiq, Humaira, Wadood, Abdul, Lu, Shaoyong, Zhang, Jian, Chen, Hai-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Binding Density Functional Theory Disulfiram - chemistry Disulfiram - pharmacology Ejection Hepacivirus - drug effects Hepatitis C Humans Molecular dynamics Molecular Dynamics Simulation Morphology Proteins Residues Viral Nonstructural Proteins - antagonists & inhibitors Zinc Zinc - chemistry Zinc - pharmacology
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