Ligand binding to G-quadruplex DNA: new insights from ultraviolet resonance Raman spectroscopy

G-Quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of several biological processes of many organisms. The rational design of G4-targeting molecules developed as potential anticancer and antiviral therapeutics is a complex problem intrinsically due to the structu...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2020-04, Vol.22 (15), p.8128-814
Hauptverfasser:	Di Fonzo, Silvia, Amato, Jussara, D'Aria, Federica, Caterino, Marco, D'Amico, Francesco, Gessini, Alessandro, Brady, John W, Cesàro, Attilio, Pagano, Bruno, Giancola, Concetta
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biological activity Circular Dichroism Dichroism DNA - chemistry G-Quadruplexes Ligands Polymorphism Protein Binding Raman spectroscopy Resonance Spectrum analysis Spectrum Analysis, Raman Topology Ultraviolet Rays Ultraviolet spectroscopy
Online-Zugang:	Volltext
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