Purine-based Ir() complexes for sensing viscosity of endo-plasmic reticulum with fluorescence lifetime imaging microscopy

Novel purine-based iridium complexes were designed for selective determination of ER viscosity. The Ir-PH possessed excellent ER targeting ability and could distinguish the viscosity changes under ER stress by fluorescence lifetime image microscopy (FLIM), which may accelerate the development of rel...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-03, Vol.57 (18), p.2265-2268
Hauptverfasser:	Liu, Xin, Li, Kun, Shi, Lei, Zhang, Hong, Liu, Yan-Hong, Wang, Hao-Yuan, Wang, Nan, Yu, Xiao-Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography Fluorescence Iridium compounds Microscopy Viscosity
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creator	Liu, Xin Li, Kun Shi, Lei Zhang, Hong Liu, Yan-Hong Wang, Hao-Yuan Wang, Nan Yu, Xiao-Qi
description	Novel purine-based iridium complexes were designed for selective determination of ER viscosity. The Ir-PH possessed excellent ER targeting ability and could distinguish the viscosity changes under ER stress by fluorescence lifetime image microscopy (FLIM), which may accelerate the development of relative quantitative detection of microenvironment changes at the subcellular level. Purine-based Ir( iii ) complexes had excellent ER targeting and could reflect the physiological state by FLIM.
doi_str_mv	10.1039/d0cc07867k
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source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Crystallography Fluorescence Iridium compounds Microscopy Viscosity
title	Purine-based Ir() complexes for sensing viscosity of endo-plasmic reticulum with fluorescence lifetime imaging microscopy
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