A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides
Hydrophilic Fe 3 O 4 @PDA@UIO-66-NH 2 is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins via LC-MS/MS. This wo...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-11, Vol.56 (9), p.13999-142 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Zhang, Ning Sun, Nianrong Deng, Chunhui |
| description | Hydrophilic Fe
3
O
4
@PDA@UIO-66-NH
2
is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins
via
LC-MS/MS. This work will make a great contribution to further functional analysis of exosomes.
Fe
3
O
4
@PDA@UIO-66-NH
2
is a biocompatible material that can be applied to enrich exosomes and phosphopeptides from urinary exosomes consecutively. |
| doi_str_mv | 10.1039/d0cc06147f |
| format | Article |
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3
O
4
@PDA@UIO-66-NH
2
is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins
via
LC-MS/MS. This work will make a great contribution to further functional analysis of exosomes.
Fe
3
O
4
@PDA@UIO-66-NH
2
is a biocompatible material that can be applied to enrich exosomes and phosphopeptides from urinary exosomes consecutively.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d0cc06147f</identifier><identifier>PMID: 33094757</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Chromatography, Liquid ; Ethical standards ; Exosomes - chemistry ; Functional analysis ; Humans ; Hydrophilicity ; Hydrophobic and Hydrophilic Interactions ; Iron oxides ; Magnetic Phenomena ; MCF-7 Cells ; Metal-Organic Frameworks - chemistry ; Particle Size ; Phosphopeptides - chemistry ; Surface Properties ; Tandem Mass Spectrometry ; Zirconium</subject><ispartof>Chemical communications (Cambridge, England), 2020-11, Vol.56 (9), p.13999-142</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-1170b83fe8ed7d3ca14dd12c36480a4ba4a7c37601b8e9df4cd4811025d1d3523</citedby><cites>FETCH-LOGICAL-c403t-1170b83fe8ed7d3ca14dd12c36480a4ba4a7c37601b8e9df4cd4811025d1d3523</cites><orcidid>0000-0002-8704-7543 ; 0000-0003-1511-7116</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33094757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ning</creatorcontrib><creatorcontrib>Sun, Nianrong</creatorcontrib><creatorcontrib>Deng, Chunhui</creatorcontrib><title>A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Hydrophilic Fe
3
O
4
@PDA@UIO-66-NH
2
is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins
via
LC-MS/MS. This work will make a great contribution to further functional analysis of exosomes.
Fe
3
O
4
@PDA@UIO-66-NH
2
is a biocompatible material that can be applied to enrich exosomes and phosphopeptides from urinary exosomes consecutively.</description><subject>Chromatography, Liquid</subject><subject>Ethical standards</subject><subject>Exosomes - chemistry</subject><subject>Functional analysis</subject><subject>Humans</subject><subject>Hydrophilicity</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Iron oxides</subject><subject>Magnetic Phenomena</subject><subject>MCF-7 Cells</subject><subject>Metal-Organic Frameworks - chemistry</subject><subject>Particle Size</subject><subject>Phosphopeptides - chemistry</subject><subject>Surface Properties</subject><subject>Tandem Mass Spectrometry</subject><subject>Zirconium</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0UFLwzAUB_AgipvTi3cl4EWEatKkbXoc06kw2UXBW0mTV9vRNjVpxX17MzcVDIS8kB-P5B-ETim5poSlN5ooRWLKk2IPjSmLeRBx8bq_qaM0SBiPRujIuRXxg0biEI0YIylPomSM8iku19qarqzqSuFGvrXQ--JpOceFsbgvASvTOlBDX30AhtZWqmyg7bEpMHwaZxpwWLZ6t5E17krj_Oyg6ysN7hgdFLJ2cLJbJ-hlfvc8ewgWy_vH2XQRKE5YH1CakFywAgToRDMlKdeahsq_RxDJc8llolgSE5oLSHXBleaCUhJGmmoWhWyCLrd9O2veB3B91lROQV3LFszgspBHnBKRCubpxT-6MoNt_e02Ko1DEafUq6utUtY4Z6HIOls10q4zSrJN8tktmc2-k597fL5rOeQN6F_6E7UHZ1tgnfo9_fs69gU3EYg7</recordid><startdate>20201112</startdate><enddate>20201112</enddate><creator>Zhang, Ning</creator><creator>Sun, Nianrong</creator><creator>Deng, Chunhui</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8704-7543</orcidid><orcidid>https://orcid.org/0000-0003-1511-7116</orcidid></search><sort><creationdate>20201112</creationdate><title>A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides</title><author>Zhang, Ning ; Sun, Nianrong ; Deng, Chunhui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-1170b83fe8ed7d3ca14dd12c36480a4ba4a7c37601b8e9df4cd4811025d1d3523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chromatography, Liquid</topic><topic>Ethical standards</topic><topic>Exosomes - chemistry</topic><topic>Functional analysis</topic><topic>Humans</topic><topic>Hydrophilicity</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Iron oxides</topic><topic>Magnetic Phenomena</topic><topic>MCF-7 Cells</topic><topic>Metal-Organic Frameworks - chemistry</topic><topic>Particle Size</topic><topic>Phosphopeptides - chemistry</topic><topic>Surface Properties</topic><topic>Tandem Mass Spectrometry</topic><topic>Zirconium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ning</creatorcontrib><creatorcontrib>Sun, Nianrong</creatorcontrib><creatorcontrib>Deng, Chunhui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ning</au><au>Sun, Nianrong</au><au>Deng, Chunhui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2020-11-12</date><risdate>2020</risdate><volume>56</volume><issue>9</issue><spage>13999</spage><epage>142</epage><pages>13999-142</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Hydrophilic Fe
3
O
4
@PDA@UIO-66-NH
2
is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins
via
LC-MS/MS. This work will make a great contribution to further functional analysis of exosomes.
Fe
3
O
4
@PDA@UIO-66-NH
2
is a biocompatible material that can be applied to enrich exosomes and phosphopeptides from urinary exosomes consecutively.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33094757</pmid><doi>10.1039/d0cc06147f</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8704-7543</orcidid><orcidid>https://orcid.org/0000-0003-1511-7116</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2020-11, Vol.56 (9), p.13999-142 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_rsc_primary_d0cc06147f |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Chromatography, Liquid Ethical standards Exosomes - chemistry Functional analysis Humans Hydrophilicity Hydrophobic and Hydrophilic Interactions Iron oxides Magnetic Phenomena MCF-7 Cells Metal-Organic Frameworks - chemistry Particle Size Phosphopeptides - chemistry Surface Properties Tandem Mass Spectrometry Zirconium |
| title | A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides |
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