Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables MRI probe quantification
We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd( iii ) chelates, able to generate a quantitative 19 F MRI signal, while in parallel capable of modulating the 1 H MRI signal in response to the coordination of Ca 2+ ions. Subsequently, we performed experiments i...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (66), p.9433-9436 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9436 |
|---|---|
| container_issue | 66 |
| container_start_page | 9433 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 56 |
| creator | Gambino, Giuseppe Gambino, Tanja Angelovski, Goran |
| description | We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(
iii
) chelates, able to generate a quantitative
19
F MRI signal, while in parallel capable of modulating the
1
H MRI signal in response to the coordination of Ca
2+
ions. Subsequently, we performed experiments
in vivo
and estimated the concentration of the applied probe in the tissue by means of
19
F MRI.
We used lipid nanoparticles with a perfluorinated core as a platform for a responsive nanosized
1
H MRI contrast agent to achieve the
in vivo
quantification of the probe by means of
19
F MRI. |
| doi_str_mv | 10.1039/d0cc04416d |
| format | Article |
| fullrecord | <record><control><sourceid>rsc</sourceid><recordid>TN_cdi_rsc_primary_d0cc04416d</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>d0cc04416d</sourcerecordid><originalsourceid>FETCH-rsc_primary_d0cc04416d3</originalsourceid><addsrcrecordid>eNqFj0tLBDEQhMOisOvj4l1of8BoQjL7OC-KHvYiHrwNPUkHWzJJNpkV_PfuiOBN61IFX0FRQlwpeauk3tw5aa00Ri3dTCyUXpqmNevXkym3m2alTTsXZ7W-y6NUu16IYZuGniOOnCIkDz2nQjWnWPmDwL5RwJEqYHSQqfhwSGVqk4PAmR1EjCljGdmGY40i9pPvnp8gl9QT7A8YR_ZsvxcuxKnHUOnyx8_F9cP9y_axKdV2ufCA5bP7_aD_5zd_8S47r78AC3NYPg</addsrcrecordid><sourcetype>Enrichment Source</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables MRI probe quantification</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Gambino, Giuseppe ; Gambino, Tanja ; Angelovski, Goran</creator><creatorcontrib>Gambino, Giuseppe ; Gambino, Tanja ; Angelovski, Goran</creatorcontrib><description>We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(
iii
) chelates, able to generate a quantitative
19
F MRI signal, while in parallel capable of modulating the
1
H MRI signal in response to the coordination of Ca
2+
ions. Subsequently, we performed experiments
in vivo
and estimated the concentration of the applied probe in the tissue by means of
19
F MRI.
We used lipid nanoparticles with a perfluorinated core as a platform for a responsive nanosized
1
H MRI contrast agent to achieve the
in vivo
quantification of the probe by means of
19
F MRI.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d0cc04416d</identifier><language>eng</language><ispartof>Chemical communications (Cambridge, England), 2020-08, Vol.56 (66), p.9433-9436</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Gambino, Giuseppe</creatorcontrib><creatorcontrib>Gambino, Tanja</creatorcontrib><creatorcontrib>Angelovski, Goran</creatorcontrib><title>Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables MRI probe quantification</title><title>Chemical communications (Cambridge, England)</title><description>We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(
iii
) chelates, able to generate a quantitative
19
F MRI signal, while in parallel capable of modulating the
1
H MRI signal in response to the coordination of Ca
2+
ions. Subsequently, we performed experiments
in vivo
and estimated the concentration of the applied probe in the tissue by means of
19
F MRI.
We used lipid nanoparticles with a perfluorinated core as a platform for a responsive nanosized
1
H MRI contrast agent to achieve the
in vivo
quantification of the probe by means of
19
F MRI.</description><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFj0tLBDEQhMOisOvj4l1of8BoQjL7OC-KHvYiHrwNPUkHWzJJNpkV_PfuiOBN61IFX0FRQlwpeauk3tw5aa00Ri3dTCyUXpqmNevXkym3m2alTTsXZ7W-y6NUu16IYZuGniOOnCIkDz2nQjWnWPmDwL5RwJEqYHSQqfhwSGVqk4PAmR1EjCljGdmGY40i9pPvnp8gl9QT7A8YR_ZsvxcuxKnHUOnyx8_F9cP9y_axKdV2ufCA5bP7_aD_5zd_8S47r78AC3NYPg</recordid><startdate>20200819</startdate><enddate>20200819</enddate><creator>Gambino, Giuseppe</creator><creator>Gambino, Tanja</creator><creator>Angelovski, Goran</creator><scope/></search><sort><creationdate>20200819</creationdate><title>Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables MRI probe quantification</title><author>Gambino, Giuseppe ; Gambino, Tanja ; Angelovski, Goran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_d0cc04416d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Gambino, Giuseppe</creatorcontrib><creatorcontrib>Gambino, Tanja</creatorcontrib><creatorcontrib>Angelovski, Goran</creatorcontrib><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gambino, Giuseppe</au><au>Gambino, Tanja</au><au>Angelovski, Goran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables MRI probe quantification</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2020-08-19</date><risdate>2020</risdate><volume>56</volume><issue>66</issue><spage>9433</spage><epage>9436</epage><pages>9433-9436</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(
iii
) chelates, able to generate a quantitative
19
F MRI signal, while in parallel capable of modulating the
1
H MRI signal in response to the coordination of Ca
2+
ions. Subsequently, we performed experiments
in vivo
and estimated the concentration of the applied probe in the tissue by means of
19
F MRI.
We used lipid nanoparticles with a perfluorinated core as a platform for a responsive nanosized
1
H MRI contrast agent to achieve the
in vivo
quantification of the probe by means of
19
F MRI.</abstract><doi>10.1039/d0cc04416d</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2020-08, Vol.56 (66), p.9433-9436 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_rsc_primary_d0cc04416d |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables MRI probe quantification |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A08%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-rsc&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combination%20of%20bioresponsive%20chelates%20and%20perfluorinated%20lipid%20nanoparticles%20enables%20MRI%20probe%20quantification&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Gambino,%20Giuseppe&rft.date=2020-08-19&rft.volume=56&rft.issue=66&rft.spage=9433&rft.epage=9436&rft.pages=9433-9436&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/d0cc04416d&rft_dat=%3Crsc%3Ed0cc04416d%3C/rsc%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |