Growth factor-mimicking 3,4-dihydroxyphenylalanine-encoded bioartificial extracellular matrix like protein promotes wound closure and angiogenesis

The present work reports a new route to prepare a "smart biomaterial" by mimicking long-acting cellular growth factor showing enhanced cell-material interactions by promoting cell proliferation and angiogenesis. For that, reactive non-proteogenic amino acid 3,4-dihydroxyphenylalanine (DOPA...

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Veröffentlicht in:	Biomaterials science 2020-12, Vol.8 (23), p.6773-6785
Hauptverfasser:	Ilamaran, Meganathan, Sundarapandian, Ashokraj, Aarthy, Mayilvahanan, Shanmugam, Ganesh, Ponesakki, Ganesan, Ramudu, Kamini Numbi, Niraikulam, Ayyadurai
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biocompatibility Biocompatible Materials Biomedical materials Catechol Cell adhesion & migration Cell growth Collagen Crosslinking Dihydroxyphenylalanine Dihydroxyphenylalanine - pharmacology Extracellular Matrix Growth factors Molecular structure Neovascularization, Physiologic Proteins Self-assembly Smart materials Structural hierarchy Surgical implants Tissue engineering Turbidity Vascular Endothelial Growth Factor A Wound Healing
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