Comparison of sample preparation methodologies towards optimisation of Raman spectroscopy for peripheral blood mononuclear cells

The exquisite sensitivity of Raman spectroscopy to the molecular composition of biological samples has been a particular strength in its development towards clinical applicates. Its strength in this regard also presents challenges in the development of its diagnostic capabilities owing to its sensit...

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Veröffentlicht in:	Analytical methods 2021-02, Vol.13 (8), p.119-132
Hauptverfasser:	Chaudhary, Neha, Que Nguyen, Thi Nguyet, Maguire, Adrian, Wynne, Claire, Meade, Aidan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological properties Biological samples Blood Cell culture Chemical composition Clonal selection Contamination Hemoglobin Immune system Leukocytes Leukocytes, Mononuclear Lymphocytes Monoclonal antibodies Negative selection Optimization Peripheral blood mononuclear cells Peroxide Purification Raman spectroscopy Sample preparation Sensitivity Specimen Handling Spectra Spectroscopic analysis Spectroscopy Spectrum analysis Spectrum Analysis, Raman Subpopulations
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