Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO 2 ) towards cancer cells has been reported previously, but the...
Gespeichert in:
| Veröffentlicht in: | Toxicology research (Cambridge) 2019-11, Vol.8 (6), p.142-149 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 149 |
|---|---|
| container_issue | 6 |
| container_start_page | 142 |
| container_title | Toxicology research (Cambridge) |
| container_volume | 8 |
| creator | Niu, Yuexiang Tang, Engong Zhang, Qingan |
| description | Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO
2
) towards cancer cells has been reported previously, but the specific mechanism is not fully clear. In this study, Nano-SiO
2
showed a remarkable cytotoxic effect against HCC cells, regardless of whether the cells were drug resistant or not. Further study showed that Nano-SiO
2
treatment leads to cell cycle arrest, apoptosis enhancement and necroptosis induction in the HCC cells. RNA-seq data, together with bioinformatics analysis, revealed that a series of genes involved in cancer cell death could be regulated by Nano-SiO
2
, among which ZBP-1 was up-regulated the most by Nano-SiO
2
treatment. The siRNA based experiments demonstrated that ZBP-1 might play a key role in mediating Nano-SiO
2
cytotoxic functions against HCC cells. These results have evidently signified the anti-tumor potential of Nano-SiO
2
in the treatment of HCC.
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. |
| doi_str_mv | 10.1039/c9tx00240e |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_rsc_primary_c9tx00240e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2322620564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-861b7bd0b029cd9ac3b411358698138d3e31841f188ec1a228e209125d62335e3</originalsourceid><addsrcrecordid>eNp9kcFrFDEUxoMottRevCsRL0VYTV4mM5lLQZaqhUIvCt5CJvNmN2UmGZOMtP-9WbautofmkpDvx8f33kfIa84-cibaT7bNt4xBxfAZOQZWyVUlhXp-eMPPI3Ka0g0rp2FQC_mSHAngUjQNOybT-i6HHG6dpTgMaDMNA01udNZQb3yYTczOjpio2RjnU6ZbnE0OFsdxGU2k1kTrfJgM3X0lmrcxLJst9WhjmHNILlHn-8VmF_wr8mIwY8LT-_uE_Phy8X39bXV1_fVy_flqZStZ5ZWqedd0PesYtLZvjRVdxbmQqm4VF6oXKLiq-MCVQssNgEJgLQfZ1yCERHFCzve-89JN2Fv0OZpRz9FNJt7pYJx-qHi31ZvwW5cNcd5CMTi7N4jh14Ip68ml3YDGY1iSBtGUNKIFXtD3j9CbsERfxisUQA1M1lWhPuypspWUIg6HMJzpXZH6X5EFfvt__AP6t7YCvNkDMdmD-sDg3VO6nvtB_AGSkbB1</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2322620564</pqid></control><display><type>article</type><title>Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction</title><source>Oxford University Press Journals</source><source>Royal Society Of Chemistry Journals 2008-</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Niu, Yuexiang ; Tang, Engong ; Zhang, Qingan</creator><creatorcontrib>Niu, Yuexiang ; Tang, Engong ; Zhang, Qingan</creatorcontrib><description>Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO
2
) towards cancer cells has been reported previously, but the specific mechanism is not fully clear. In this study, Nano-SiO
2
showed a remarkable cytotoxic effect against HCC cells, regardless of whether the cells were drug resistant or not. Further study showed that Nano-SiO
2
treatment leads to cell cycle arrest, apoptosis enhancement and necroptosis induction in the HCC cells. RNA-seq data, together with bioinformatics analysis, revealed that a series of genes involved in cancer cell death could be regulated by Nano-SiO
2
, among which ZBP-1 was up-regulated the most by Nano-SiO
2
treatment. The siRNA based experiments demonstrated that ZBP-1 might play a key role in mediating Nano-SiO
2
cytotoxic functions against HCC cells. These results have evidently signified the anti-tumor potential of Nano-SiO
2
in the treatment of HCC.
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.</description><identifier>ISSN: 2045-452X</identifier><identifier>ISSN: 2045-4538</identifier><identifier>EISSN: 2045-4538</identifier><identifier>DOI: 10.1039/c9tx00240e</identifier><identifier>PMID: 32153770</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Apoptosis ; Bioinformatics ; Cancer ; Cell cycle ; Cell death ; Chemistry ; Cytotoxicity ; Drug resistance ; Hepatocellular carcinoma ; Liver cancer ; Morbidity ; Nanoparticles ; Necroptosis ; Silica ; Silicon dioxide ; siRNA ; Toxicity</subject><ispartof>Toxicology research (Cambridge), 2019-11, Vol.8 (6), p.142-149</ispartof><rights>This journal is © The Royal Society of Chemistry 2019.</rights><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-861b7bd0b029cd9ac3b411358698138d3e31841f188ec1a228e209125d62335e3</citedby><cites>FETCH-LOGICAL-c454t-861b7bd0b029cd9ac3b411358698138d3e31841f188ec1a228e209125d62335e3</cites><orcidid>0000-0003-0356-1754</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021192/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021192/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32153770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niu, Yuexiang</creatorcontrib><creatorcontrib>Tang, Engong</creatorcontrib><creatorcontrib>Zhang, Qingan</creatorcontrib><title>Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction</title><title>Toxicology research (Cambridge)</title><addtitle>Toxicol Res (Camb)</addtitle><description>Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO
2
) towards cancer cells has been reported previously, but the specific mechanism is not fully clear. In this study, Nano-SiO
2
showed a remarkable cytotoxic effect against HCC cells, regardless of whether the cells were drug resistant or not. Further study showed that Nano-SiO
2
treatment leads to cell cycle arrest, apoptosis enhancement and necroptosis induction in the HCC cells. RNA-seq data, together with bioinformatics analysis, revealed that a series of genes involved in cancer cell death could be regulated by Nano-SiO
2
, among which ZBP-1 was up-regulated the most by Nano-SiO
2
treatment. The siRNA based experiments demonstrated that ZBP-1 might play a key role in mediating Nano-SiO
2
cytotoxic functions against HCC cells. These results have evidently signified the anti-tumor potential of Nano-SiO
2
in the treatment of HCC.
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.</description><subject>Apoptosis</subject><subject>Bioinformatics</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Chemistry</subject><subject>Cytotoxicity</subject><subject>Drug resistance</subject><subject>Hepatocellular carcinoma</subject><subject>Liver cancer</subject><subject>Morbidity</subject><subject>Nanoparticles</subject><subject>Necroptosis</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>siRNA</subject><subject>Toxicity</subject><issn>2045-452X</issn><issn>2045-4538</issn><issn>2045-4538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kcFrFDEUxoMottRevCsRL0VYTV4mM5lLQZaqhUIvCt5CJvNmN2UmGZOMtP-9WbautofmkpDvx8f33kfIa84-cibaT7bNt4xBxfAZOQZWyVUlhXp-eMPPI3Ka0g0rp2FQC_mSHAngUjQNOybT-i6HHG6dpTgMaDMNA01udNZQb3yYTczOjpio2RjnU6ZbnE0OFsdxGU2k1kTrfJgM3X0lmrcxLJst9WhjmHNILlHn-8VmF_wr8mIwY8LT-_uE_Phy8X39bXV1_fVy_flqZStZ5ZWqedd0PesYtLZvjRVdxbmQqm4VF6oXKLiq-MCVQssNgEJgLQfZ1yCERHFCzve-89JN2Fv0OZpRz9FNJt7pYJx-qHi31ZvwW5cNcd5CMTi7N4jh14Ip68ml3YDGY1iSBtGUNKIFXtD3j9CbsERfxisUQA1M1lWhPuypspWUIg6HMJzpXZH6X5EFfvt__AP6t7YCvNkDMdmD-sDg3VO6nvtB_AGSkbB1</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Niu, Yuexiang</creator><creator>Tang, Engong</creator><creator>Zhang, Qingan</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0356-1754</orcidid></search><sort><creationdate>20191101</creationdate><title>Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction</title><author>Niu, Yuexiang ; Tang, Engong ; Zhang, Qingan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-861b7bd0b029cd9ac3b411358698138d3e31841f188ec1a228e209125d62335e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apoptosis</topic><topic>Bioinformatics</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Chemistry</topic><topic>Cytotoxicity</topic><topic>Drug resistance</topic><topic>Hepatocellular carcinoma</topic><topic>Liver cancer</topic><topic>Morbidity</topic><topic>Nanoparticles</topic><topic>Necroptosis</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>siRNA</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niu, Yuexiang</creatorcontrib><creatorcontrib>Tang, Engong</creatorcontrib><creatorcontrib>Zhang, Qingan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Toxicology research (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niu, Yuexiang</au><au>Tang, Engong</au><au>Zhang, Qingan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction</atitle><jtitle>Toxicology research (Cambridge)</jtitle><addtitle>Toxicol Res (Camb)</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>8</volume><issue>6</issue><spage>142</spage><epage>149</epage><pages>142-149</pages><issn>2045-452X</issn><issn>2045-4538</issn><eissn>2045-4538</eissn><abstract>Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO
2
) towards cancer cells has been reported previously, but the specific mechanism is not fully clear. In this study, Nano-SiO
2
showed a remarkable cytotoxic effect against HCC cells, regardless of whether the cells were drug resistant or not. Further study showed that Nano-SiO
2
treatment leads to cell cycle arrest, apoptosis enhancement and necroptosis induction in the HCC cells. RNA-seq data, together with bioinformatics analysis, revealed that a series of genes involved in cancer cell death could be regulated by Nano-SiO
2
, among which ZBP-1 was up-regulated the most by Nano-SiO
2
treatment. The siRNA based experiments demonstrated that ZBP-1 might play a key role in mediating Nano-SiO
2
cytotoxic functions against HCC cells. These results have evidently signified the anti-tumor potential of Nano-SiO
2
in the treatment of HCC.
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32153770</pmid><doi>10.1039/c9tx00240e</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0356-1754</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-452X |
| ispartof | Toxicology research (Cambridge), 2019-11, Vol.8 (6), p.142-149 |
| issn | 2045-452X 2045-4538 2045-4538 |
| language | eng |
| recordid | cdi_rsc_primary_c9tx00240e |
| source | Oxford University Press Journals; Royal Society Of Chemistry Journals 2008-; PubMed Central; Alma/SFX Local Collection |
| subjects | Apoptosis Bioinformatics Cancer Cell cycle Cell death Chemistry Cytotoxicity Drug resistance Hepatocellular carcinoma Liver cancer Morbidity Nanoparticles Necroptosis Silica Silicon dioxide siRNA Toxicity |
| title | Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T16%3A58%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_rsc_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytotoxic%20effect%20of%20silica%20nanoparticles%20against%20hepatocellular%20carcinoma%20cells%20through%20necroptosis%20induction&rft.jtitle=Toxicology%20research%20(Cambridge)&rft.au=Niu,%20Yuexiang&rft.date=2019-11-01&rft.volume=8&rft.issue=6&rft.spage=142&rft.epage=149&rft.pages=142-149&rft.issn=2045-452X&rft.eissn=2045-4538&rft_id=info:doi/10.1039/c9tx00240e&rft_dat=%3Cproquest_rsc_p%3E2322620564%3C/proquest_rsc_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2322620564&rft_id=info:pmid/32153770&rfr_iscdi=true |