A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9tb00454h

A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9tb00454h

Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectivel...

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Hauptverfasser: Balakrishnan, Biji, Joshi, Nitin, Thorat, Ketan, Kaur, Shahdeep, Chandan, Rajeet, Banerjee, Rinti
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Thorat, Ketan
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description Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectively to achieve a triggered release of doxorubicin in tumor milieu. Doxorubicin prodrug hydrogel doped with miltefosine demonstrated a synergistic effect on inhibition of drug resistant MDA-MB 231 human breast cancer cells, suitable for focal combination chemotherapy. Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy.
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title A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9tb00454h
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