Diterpenoids from and their nitric oxide production inhibitory activity
Six new ent -kaurane diterpenoids, isodonrubescins A-F ( 1-6 ), together with twenty-five known ent -kaurane diterpenoids ( 7-31 ), a known ent -atisane diterpenoid ( 32 ), and two known ent -abietane diterpenoids ( 33-34 ), were isolated from Isodon rubescens . Their structures were established by...
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| Veröffentlicht in: | RSC advances 2019-12, Vol.9 (69), p.4628-4635 |
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| creator | Wen, Chumao Chen, Su Yuan, Fang Liu, Xiangming Song, Fajun Mei, Zhinan Yang, Xiaofei Yang, Guangzhong |
| description | Six new
ent
-kaurane diterpenoids, isodonrubescins A-F (
1-6
), together with twenty-five known
ent
-kaurane diterpenoids (
7-31
), a known
ent
-atisane diterpenoid (
32
), and two known
ent
-abietane diterpenoids (
33-34
), were isolated from
Isodon rubescens
. Their structures were established by means of extensive MS and NMR data analysis. Among the all isolates, compound
7
was found in a natural product for the first time, and
ent
-atisane diterpenoid was discovered from
I. rubescens
in Hubei Province, P. R. China for the first time. Furthermore, all the isolated compounds were tested for their NO production inhibitory activity in LPS stimulated RAW264.7 cells. Compounds
7-9
,
12
,
13
,
16
, and
17
displayed NO production inhibitory activities with IC
50
values ranging from 1.36 to 18.25 μM, respectively.
Six previously undescribed
ent
-kaurane diterpenoids, including two 6,7-
seco-ent
-kaurane diterpenoids (
1-2
), four 7,20-epoxy-
ent
-kaurane diterpenoids (
3-6
) were isolated from
I. rubescens
. |
| doi_str_mv | 10.1039/c9ra08831h |
| format | Article |
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ent
-kaurane diterpenoids, isodonrubescins A-F (
1-6
), together with twenty-five known
ent
-kaurane diterpenoids (
7-31
), a known
ent
-atisane diterpenoid (
32
), and two known
ent
-abietane diterpenoids (
33-34
), were isolated from
Isodon rubescens
. Their structures were established by means of extensive MS and NMR data analysis. Among the all isolates, compound
7
was found in a natural product for the first time, and
ent
-atisane diterpenoid was discovered from
I. rubescens
in Hubei Province, P. R. China for the first time. Furthermore, all the isolated compounds were tested for their NO production inhibitory activity in LPS stimulated RAW264.7 cells. Compounds
7-9
,
12
,
13
,
16
, and
17
displayed NO production inhibitory activities with IC
50
values ranging from 1.36 to 18.25 μM, respectively.
Six previously undescribed
ent
-kaurane diterpenoids, including two 6,7-
seco-ent
-kaurane diterpenoids (
1-2
), four 7,20-epoxy-
ent
-kaurane diterpenoids (
3-6
) were isolated from
I. rubescens
.</description><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c9ra08831h</identifier><language>eng</language><ispartof>RSC advances, 2019-12, Vol.9 (69), p.4628-4635</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,866,27933,27934</link.rule.ids></links><search><creatorcontrib>Wen, Chumao</creatorcontrib><creatorcontrib>Chen, Su</creatorcontrib><creatorcontrib>Yuan, Fang</creatorcontrib><creatorcontrib>Liu, Xiangming</creatorcontrib><creatorcontrib>Song, Fajun</creatorcontrib><creatorcontrib>Mei, Zhinan</creatorcontrib><creatorcontrib>Yang, Xiaofei</creatorcontrib><creatorcontrib>Yang, Guangzhong</creatorcontrib><title>Diterpenoids from and their nitric oxide production inhibitory activity</title><title>RSC advances</title><description>Six new
ent
-kaurane diterpenoids, isodonrubescins A-F (
1-6
), together with twenty-five known
ent
-kaurane diterpenoids (
7-31
), a known
ent
-atisane diterpenoid (
32
), and two known
ent
-abietane diterpenoids (
33-34
), were isolated from
Isodon rubescens
. Their structures were established by means of extensive MS and NMR data analysis. Among the all isolates, compound
7
was found in a natural product for the first time, and
ent
-atisane diterpenoid was discovered from
I. rubescens
in Hubei Province, P. R. China for the first time. Furthermore, all the isolated compounds were tested for their NO production inhibitory activity in LPS stimulated RAW264.7 cells. Compounds
7-9
,
12
,
13
,
16
, and
17
displayed NO production inhibitory activities with IC
50
values ranging from 1.36 to 18.25 μM, respectively.
Six previously undescribed
ent
-kaurane diterpenoids, including two 6,7-
seco-ent
-kaurane diterpenoids (
1-2
), four 7,20-epoxy-
ent
-kaurane diterpenoids (
3-6
) were isolated from
I. rubescens
.</description><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFjr0KwjAURoMgWLSLuxAfoJq0GtrZ3wdwLzFJ6RWbhJso9u3tILjptxw4Z_kImXO24qyo1qpCycqy4O2IJDnbiCxnopqQNIQbGya2PBc8Iac9RIPeWAc60AZdR6XVNLYGkFqICIq6F2hDPTr9UBGcpWBbuEJ02FM5mCfEfkbGjbwHk344JYvj4bI7ZxhU7RE6iX39PVX878tfvfa6Kd5Yw0jX</recordid><startdate>20191209</startdate><enddate>20191209</enddate><creator>Wen, Chumao</creator><creator>Chen, Su</creator><creator>Yuan, Fang</creator><creator>Liu, Xiangming</creator><creator>Song, Fajun</creator><creator>Mei, Zhinan</creator><creator>Yang, Xiaofei</creator><creator>Yang, Guangzhong</creator><scope/></search><sort><creationdate>20191209</creationdate><title>Diterpenoids from and their nitric oxide production inhibitory activity</title><author>Wen, Chumao ; Chen, Su ; Yuan, Fang ; Liu, Xiangming ; Song, Fajun ; Mei, Zhinan ; Yang, Xiaofei ; Yang, Guangzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c9ra08831h3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wen, Chumao</creatorcontrib><creatorcontrib>Chen, Su</creatorcontrib><creatorcontrib>Yuan, Fang</creatorcontrib><creatorcontrib>Liu, Xiangming</creatorcontrib><creatorcontrib>Song, Fajun</creatorcontrib><creatorcontrib>Mei, Zhinan</creatorcontrib><creatorcontrib>Yang, Xiaofei</creatorcontrib><creatorcontrib>Yang, Guangzhong</creatorcontrib><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wen, Chumao</au><au>Chen, Su</au><au>Yuan, Fang</au><au>Liu, Xiangming</au><au>Song, Fajun</au><au>Mei, Zhinan</au><au>Yang, Xiaofei</au><au>Yang, Guangzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diterpenoids from and their nitric oxide production inhibitory activity</atitle><jtitle>RSC advances</jtitle><date>2019-12-09</date><risdate>2019</risdate><volume>9</volume><issue>69</issue><spage>4628</spage><epage>4635</epage><pages>4628-4635</pages><eissn>2046-2069</eissn><abstract>Six new
ent
-kaurane diterpenoids, isodonrubescins A-F (
1-6
), together with twenty-five known
ent
-kaurane diterpenoids (
7-31
), a known
ent
-atisane diterpenoid (
32
), and two known
ent
-abietane diterpenoids (
33-34
), were isolated from
Isodon rubescens
. Their structures were established by means of extensive MS and NMR data analysis. Among the all isolates, compound
7
was found in a natural product for the first time, and
ent
-atisane diterpenoid was discovered from
I. rubescens
in Hubei Province, P. R. China for the first time. Furthermore, all the isolated compounds were tested for their NO production inhibitory activity in LPS stimulated RAW264.7 cells. Compounds
7-9
,
12
,
13
,
16
, and
17
displayed NO production inhibitory activities with IC
50
values ranging from 1.36 to 18.25 μM, respectively.
Six previously undescribed
ent
-kaurane diterpenoids, including two 6,7-
seco-ent
-kaurane diterpenoids (
1-2
), four 7,20-epoxy-
ent
-kaurane diterpenoids (
3-6
) were isolated from
I. rubescens
.</abstract><doi>10.1039/c9ra08831h</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2046-2069 |
| ispartof | RSC advances, 2019-12, Vol.9 (69), p.4628-4635 |
| issn | 2046-2069 |
| language | eng |
| recordid | cdi_rsc_primary_c9ra08831h |
| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| title | Diterpenoids from and their nitric oxide production inhibitory activity |
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