Transition metal-free one-pot synthesis of substituted pyrroles by employing aza-Wittig reaction
A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides. This method does not compromise the diverse substitutions on both the phenacyl...
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| Veröffentlicht in: | RSC advances 2019-09, Vol.9 (53), p.3659-3665 |
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| container_issue | 53 |
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| container_title | RSC advances |
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| creator | Jadala, Chetna Prasad, Budaganaboyina Prasanthi, A. V. G Shankaraiah, Nagula Kamal, Ahmed |
| description | A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides. This method does not compromise the diverse substitutions on both the phenacyl azides and chromones. The merits of this method are wide substrate scope, easy functionalization, short reaction time, operationally simple, and higher yields. Moreover, this method is amenable for the generation of a library of key pyrrole building blocks.
A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides. |
| doi_str_mv | 10.1039/c9ra06778g |
| format | Article |
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A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c9ra06778g</identifier><identifier>PMID: 35529397</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Chemistry ; Pyrroles ; Reaction time ; Substitutes ; Substrates ; Transition metals</subject><ispartof>RSC advances, 2019-09, Vol.9 (53), p.3659-3665</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-1959c395725e474ca370b6801c9a7917d7b2b33bcf1b324f15d140e515c29d6c3</citedby><cites>FETCH-LOGICAL-c494t-1959c395725e474ca370b6801c9a7917d7b2b33bcf1b324f15d140e515c29d6c3</cites><orcidid>0000-0002-5750-2920 ; 0000-0002-7532-9578</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072206/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072206/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35529397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jadala, Chetna</creatorcontrib><creatorcontrib>Prasad, Budaganaboyina</creatorcontrib><creatorcontrib>Prasanthi, A. V. G</creatorcontrib><creatorcontrib>Shankaraiah, Nagula</creatorcontrib><creatorcontrib>Kamal, Ahmed</creatorcontrib><title>Transition metal-free one-pot synthesis of substituted pyrroles by employing aza-Wittig reaction</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides. This method does not compromise the diverse substitutions on both the phenacyl azides and chromones. The merits of this method are wide substrate scope, easy functionalization, short reaction time, operationally simple, and higher yields. Moreover, this method is amenable for the generation of a library of key pyrrole building blocks.
A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides.</description><subject>Chemistry</subject><subject>Pyrroles</subject><subject>Reaction time</subject><subject>Substitutes</subject><subject>Substrates</subject><subject>Transition metals</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkd1rFTEQxYMottS--K4EfBFhNd-5eRHKxVahIEjFx5jNzt6m7CZrkhXWv75bb71W52UGzo_DzByEnlPylhJu3nmTHVFab3aP0DEjQjWMKPP4wXyETku5IWspSZmiT9ERl5IZbvQx-n6VXSyhhhTxCNUNTZ8BcIrQTKnissR6DSUUnHpc5rbUUOcKHZ6WnNMABbcLhnEa0hLiDrtfrvkWag07nMH5O9dn6EnvhgKn9_0EfT3_cLX92Fx-vvi0PbtsvDCiNtRI47mRmkkQWnjHNWnVhlBvnDZUd7plLeet72nLmeip7KggIKn0zHTK8xP0fu87ze0InYdYsxvslMPo8mKTC_ZfJYZru0s_rSGarW9aDV7fG-T0Y4ZS7RiKh2FwEdJcLFOKig1nmq_oq__QmzTnuJ5nGSdUKMO0Wak3e8rnVEqG_rAMJfYuO7s1X85-Z3exwi8frn9A_yS1Ai_2QC7-oP4Nn98CS_2fdg</recordid><startdate>20190927</startdate><enddate>20190927</enddate><creator>Jadala, Chetna</creator><creator>Prasad, Budaganaboyina</creator><creator>Prasanthi, A. V. G</creator><creator>Shankaraiah, Nagula</creator><creator>Kamal, Ahmed</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5750-2920</orcidid><orcidid>https://orcid.org/0000-0002-7532-9578</orcidid></search><sort><creationdate>20190927</creationdate><title>Transition metal-free one-pot synthesis of substituted pyrroles by employing aza-Wittig reaction</title><author>Jadala, Chetna ; Prasad, Budaganaboyina ; Prasanthi, A. V. G ; Shankaraiah, Nagula ; Kamal, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-1959c395725e474ca370b6801c9a7917d7b2b33bcf1b324f15d140e515c29d6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chemistry</topic><topic>Pyrroles</topic><topic>Reaction time</topic><topic>Substitutes</topic><topic>Substrates</topic><topic>Transition metals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jadala, Chetna</creatorcontrib><creatorcontrib>Prasad, Budaganaboyina</creatorcontrib><creatorcontrib>Prasanthi, A. V. G</creatorcontrib><creatorcontrib>Shankaraiah, Nagula</creatorcontrib><creatorcontrib>Kamal, Ahmed</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jadala, Chetna</au><au>Prasad, Budaganaboyina</au><au>Prasanthi, A. V. G</au><au>Shankaraiah, Nagula</au><au>Kamal, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transition metal-free one-pot synthesis of substituted pyrroles by employing aza-Wittig reaction</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2019-09-27</date><risdate>2019</risdate><volume>9</volume><issue>53</issue><spage>3659</spage><epage>3665</epage><pages>3659-3665</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>A mild and metal-free one-pot synthetic strategy has been developed for the construction of substituted pyrroles by employing aza-Wittig reaction from a unique and unexplored combination of chromones and phenacyl azides. This method does not compromise the diverse substitutions on both the phenacyl azides and chromones. The merits of this method are wide substrate scope, easy functionalization, short reaction time, operationally simple, and higher yields. Moreover, this method is amenable for the generation of a library of key pyrrole building blocks.
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Chemistry Pyrroles Reaction time Substitutes Substrates Transition metals |
| title | Transition metal-free one-pot synthesis of substituted pyrroles by employing aza-Wittig reaction |
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