Molecular interaction studies on ellagic acid for its anticancer potential targeting pyruvate dehydrogenase kinase 3

Pyruvate dehydrogenase kinase 3 (PDK3) plays a central role in the cancer metabolic switch through the reversible phosphorylation of pyruvate dehydrogenase complex thereby blocking the entry of pyruvate for its catabolism into the TCA cycle, and thus it is considered as an important drug target for...

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Veröffentlicht in:	RSC advances 2019-07, Vol.9 (4), p.2332-23315
Hauptverfasser:	Dahiya, Rashmi, Mohammad, Taj, Gupta, Preeti, Haque, Anzarul, Alajmi, Mohamed F, Hussain, Afzal, Hassan, Md. Imtaiyaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Catabolism Chemistry Dehydrogenases Fluorescence Hydrogen bonds Kinases Molecular docking Molecular dynamics Molecular interactions Phosphorylation Polyphenols Titration calorimetry Toxicity
Online-Zugang:	Volltext
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