Synthesis of 1,4-diazepinone derivatives a domino aza-Michael/S2 cyclization of 1-azadienes with α-halogenoacetamides
A novel cyclization of α-halogenoacetamides with 1-azadienes has been developed for the efficient preparation of monocyclic 1,4-diazepinones in one step under transition metal-free conditions. Various α-halogenoacetamides and 1-azadienes are well tolerated and give the desired products in good to ex...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2020-02, Vol.18 (6), p.182-186 |
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| container_end_page | 186 |
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| container_issue | 6 |
| container_start_page | 182 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 18 |
| creator | Yuan, Chunhao Zhang, Hui Yuan, Mengna Xie, Lei Cao, Xiaoqun |
| description | A novel cyclization of α-halogenoacetamides with 1-azadienes has been developed for the efficient preparation of monocyclic 1,4-diazepinones in one step under transition metal-free conditions. Various α-halogenoacetamides and 1-azadienes are well tolerated and give the desired products in good to excellent yields. This cyclization also demonstrates potential synthetic utility on a gram-scale and further transformation.
A novel cyclization of
N
-alkoxy α-halogenoacetamides with
N
-sulfonyl-1-aza-1,3-butadienes has been developed for the efficient preparation of 1,4-diazepinones in one step under transition metal-free conditions. |
| doi_str_mv | 10.1039/c9ob02626f |
| format | Article |
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A novel cyclization of
N
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N
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A novel cyclization of
N
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N
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A novel cyclization of
N
-alkoxy α-halogenoacetamides with
N
-sulfonyl-1-aza-1,3-butadienes has been developed for the efficient preparation of 1,4-diazepinones in one step under transition metal-free conditions.</abstract><doi>10.1039/c9ob02626f</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2020-02, Vol.18 (6), p.182-186 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_rsc_primary_c9ob02626f |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Synthesis of 1,4-diazepinone derivatives a domino aza-Michael/S2 cyclization of 1-azadienes with α-halogenoacetamides |
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