Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

Glycosaminoglycan (GAG)-based biohybrid hydrogels of varied GAG content and GAG sulfation pattern were prepared and applied to sequester cytokines. The binding of strongly acidic and basic cytokines correlated with the integral space charge density of the hydrogel, while the binding of weakly charge...

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Veröffentlicht in:	Faraday discussions 2019-10, Vol.219, p.244-251
Hauptverfasser:	Freudenberg, Uwe, Atallah, Passant, Limasale, Yanuar Dwi Putra, Werner, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Charge density Click Chemistry Cytokines Cytokines - chemistry Glycosaminoglycans Glycosaminoglycans - chemistry Heparin - chemistry Humans Hydrogels Hydrogels - chemistry Polyethylene Glycols - chemistry Space charge Sulfates - chemistry Sulfation Sulfhydryl Compounds - chemistry
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Zusammenfassung:	Glycosaminoglycan (GAG)-based biohybrid hydrogels of varied GAG content and GAG sulfation pattern were prepared and applied to sequester cytokines. The binding of strongly acidic and basic cytokines correlated with the integral space charge density of the hydrogel, while the binding of weakly charged cytokines was governed by the GAG sulfation pattern. Glycosaminoglycan (GAG)-based biohybrid hydrogels of varied GAG content and GAG sulfation pattern were prepared and applied to sequester cytokines.
ISSN:	1359-6640 1364-5498
DOI:	10.1039/c9fd00016j