Brexpiprazole-catechol cocrystal: structure elucidation, excipient compatibility and stability

Brexpiprazole (BREX) is a well known drug used in the treatment of atypical psychotic disorder. BREX is known to exhibit photo-instability on granulation with the most commonly used binder, polyvinylpyrrolidone (PVP), in wet granulation. The present study reports a cocrystal of BREX with catechol (C...

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Veröffentlicht in:	CrystEngComm 2019, Vol.21 (44), p.673-678
Hauptverfasser:	Arabiani, Mohsin R, K, Bal Raju, Bhunia, Surojit, Teja, Pyla Kranthi, Lodagekar, Anurag, Chavan, Rahul B, Shastri, Nalini R, Reddy, C. Malla, Shelat, Pragna, Dave, Divyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Catechol Compatibility Crystal structure Crystallography Degradation Granulation Hydrogen bonds Incompatibility Organic chemistry Polyvinylpyrrolidone Single crystals Structural analysis X ray powder diffraction X-ray diffraction
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