Niacin-ligated platinum()-ruthenium() chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity

Niacin-ligated platinum( iv )-ruthenium( ii ) chimeric complexes ( PtRu 1-4 ) have been synthesized and evaluated for their antitumor performance. Using the optimal complex, PtRu-1 , we show that this water-soluble chimeric prodrug not only potently inhibits the metastasis and proliferation of tumor...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (2), p.369-372
Hauptverfasser:	Shu, Liwei, Ren, Lulu, Wang, Yuchen, Fang, Tao, Ye, Zhijian, Han, Weidong, Chen, Chao, Wang, Hangxiang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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