Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained HS release profiles

Temperature- and solvent-induced selective synthesis of trisulfides and disulfides is demonstrated. A remarkable selectivity was achieved using Na 2 S as a sulfur-transfer agent under mild, greener, catalyst-free and additive-free conditions. This study reveals trisulfides as a better model than dis...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-11, Vol.55 (9), p.13534-13537
Hauptverfasser: Bhattacherjee, Debojit, Sufian, Abu, Mahato, Sulendar K, Begum, Samiyara, Banerjee, Kaustav, De, Sharmistha, Srivastava, Hemant Kumar, Bhabak, Krishna P
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container_issue 9
container_start_page 13534
container_title Chemical communications (Cambridge, England)
container_volume 55
creator Bhattacherjee, Debojit
Sufian, Abu
Mahato, Sulendar K
Begum, Samiyara
Banerjee, Kaustav
De, Sharmistha
Srivastava, Hemant Kumar
Bhabak, Krishna P
description Temperature- and solvent-induced selective synthesis of trisulfides and disulfides is demonstrated. A remarkable selectivity was achieved using Na 2 S as a sulfur-transfer agent under mild, greener, catalyst-free and additive-free conditions. This study reveals trisulfides as a better model than disulfides in general for a sustained release of H 2 S and potent anti-cancer activities. Highly selective synthesis of trisulfides over disulfides is demonstrated along with their potential as anti-proliferative agents and sustained donors of H 2 S.
doi_str_mv 10.1039/c9cc05562b
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title Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained HS release profiles
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