Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasm...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2019-07, Vol.55 (57), p.8227-823 |
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| creator | Carbajo-Gordillo, Ana I Rodríguez-Lavado, Julio Jiménez Blanco, José Luis Benito, Juan M Di Giorgio, Christophe Vélaz, Itziar Tros de Ilarduya, Concepción Ortiz Mellet, Carmen García Fernández, José M |
| description | An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery
in vitro
and
in vivo
.
Trehalose Siamese twin vectors, encompassing gemini and facial amphiphilicity, promote pDNA compaction into core-shell nanocomplexes and selective delivery in the lungs. |
| doi_str_mv | 10.1039/c9cc04489b |
| format | Article |
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in vitro
and
in vivo
.
Trehalose Siamese twin vectors, encompassing gemini and facial amphiphilicity, promote pDNA compaction into core-shell nanocomplexes and selective delivery in the lungs.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c9cc04489b</identifier><identifier>PMID: 31268107</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Cell Line ; Cercopithecus aethiops ; Disaccharides ; Humans ; Mice ; Nanoparticles ; Nanostructures - chemistry ; NMR ; Nuclear magnetic resonance ; Plasmids ; Plasmids - chemistry ; Plasmids - metabolism ; Surface-Active Agents - chemistry ; Topology ; Transfection - methods ; Trehalose ; Trehalose - chemistry</subject><ispartof>Chemical communications (Cambridge, England), 2019-07, Vol.55 (57), p.8227-823</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-ebe8877e33026566d12522043c91097f196f11300c33d01086f7bdee5bdb6d13</citedby><cites>FETCH-LOGICAL-c373t-ebe8877e33026566d12522043c91097f196f11300c33d01086f7bdee5bdb6d13</cites><orcidid>0000-0002-5249-9013 ; 0000-0002-3183-3625 ; 0000-0002-6827-0387 ; 0000-0002-4391-2937 ; 0000-0003-2728-9433 ; 0000-0002-9788-1507 ; 0000-0002-7676-7721 ; 0000-0001-5230-6077 ; 0000-0001-6414-2719</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31268107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carbajo-Gordillo, Ana I</creatorcontrib><creatorcontrib>Rodríguez-Lavado, Julio</creatorcontrib><creatorcontrib>Jiménez Blanco, José Luis</creatorcontrib><creatorcontrib>Benito, Juan M</creatorcontrib><creatorcontrib>Di Giorgio, Christophe</creatorcontrib><creatorcontrib>Vélaz, Itziar</creatorcontrib><creatorcontrib>Tros de Ilarduya, Concepción</creatorcontrib><creatorcontrib>Ortiz Mellet, Carmen</creatorcontrib><creatorcontrib>García Fernández, José M</creatorcontrib><title>Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery
in vitro
and
in vivo
.
Trehalose Siamese twin vectors, encompassing gemini and facial amphiphilicity, promote pDNA compaction into core-shell nanocomplexes and selective delivery in the lungs.</description><subject>Animals</subject><subject>Cell Line</subject><subject>Cercopithecus aethiops</subject><subject>Disaccharides</subject><subject>Humans</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Nanostructures - chemistry</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Plasmids</subject><subject>Plasmids - chemistry</subject><subject>Plasmids - metabolism</subject><subject>Surface-Active Agents - chemistry</subject><subject>Topology</subject><subject>Transfection - methods</subject><subject>Trehalose</subject><subject>Trehalose - chemistry</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0d9v1SAUB3BiXNwPffFdQ-LLYlaFUmh5nFWnyaIP3gffGqCnuyyUVk67uf9ernebiYQEAp-cQ_gS8pKzd5wJ_d5p51hVNdo-IUdcqKqQVfPz6W4vdVGLSh6SY8RrlgeXzTNyKHipGs7qI3KzSbA1YUIorEHo6Q9vRkCgy62P1Izz1ucZAOmtX7Z0WaOxAShCGAqDCKMNPl6d0Y_fzmk0cXLTOAf4nc-oiT29ggi0h-BvIN3ROU0zpMUDPicHgwkIL-7XE7L5_GnTfikuv198bc8vCydqsRRgoWnqGoRgpZJK9byUZckq4TRnuh64VgPngjEnRM84a9RQ2x5A2t5mLE7I6b5s7vxrBVy60aODEEyEacWuLCVXmjdcZvrmP3o9rSnmx-2ULJWqFcvq7V65NCEmGLo5-dGku46zbhdG1-q2_RvGh4xf35dc7Qj9I334_Qxe7UFC93j7L03xB7Tcjos</recordid><startdate>20190711</startdate><enddate>20190711</enddate><creator>Carbajo-Gordillo, Ana I</creator><creator>Rodríguez-Lavado, Julio</creator><creator>Jiménez Blanco, José Luis</creator><creator>Benito, Juan M</creator><creator>Di Giorgio, Christophe</creator><creator>Vélaz, Itziar</creator><creator>Tros de Ilarduya, Concepción</creator><creator>Ortiz Mellet, Carmen</creator><creator>García Fernández, José M</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5249-9013</orcidid><orcidid>https://orcid.org/0000-0002-3183-3625</orcidid><orcidid>https://orcid.org/0000-0002-6827-0387</orcidid><orcidid>https://orcid.org/0000-0002-4391-2937</orcidid><orcidid>https://orcid.org/0000-0003-2728-9433</orcidid><orcidid>https://orcid.org/0000-0002-9788-1507</orcidid><orcidid>https://orcid.org/0000-0002-7676-7721</orcidid><orcidid>https://orcid.org/0000-0001-5230-6077</orcidid><orcidid>https://orcid.org/0000-0001-6414-2719</orcidid></search><sort><creationdate>20190711</creationdate><title>Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties</title><author>Carbajo-Gordillo, Ana I ; Rodríguez-Lavado, Julio ; Jiménez Blanco, José Luis ; Benito, Juan M ; Di Giorgio, Christophe ; Vélaz, Itziar ; Tros de Ilarduya, Concepción ; Ortiz Mellet, Carmen ; García Fernández, José M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-ebe8877e33026566d12522043c91097f196f11300c33d01086f7bdee5bdb6d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Cell Line</topic><topic>Cercopithecus aethiops</topic><topic>Disaccharides</topic><topic>Humans</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Nanostructures - chemistry</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Plasmids</topic><topic>Plasmids - chemistry</topic><topic>Plasmids - metabolism</topic><topic>Surface-Active Agents - chemistry</topic><topic>Topology</topic><topic>Transfection - methods</topic><topic>Trehalose</topic><topic>Trehalose - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carbajo-Gordillo, Ana I</creatorcontrib><creatorcontrib>Rodríguez-Lavado, Julio</creatorcontrib><creatorcontrib>Jiménez Blanco, José Luis</creatorcontrib><creatorcontrib>Benito, Juan M</creatorcontrib><creatorcontrib>Di Giorgio, Christophe</creatorcontrib><creatorcontrib>Vélaz, Itziar</creatorcontrib><creatorcontrib>Tros de Ilarduya, Concepción</creatorcontrib><creatorcontrib>Ortiz Mellet, Carmen</creatorcontrib><creatorcontrib>García Fernández, José M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carbajo-Gordillo, Ana I</au><au>Rodríguez-Lavado, Julio</au><au>Jiménez Blanco, José Luis</au><au>Benito, Juan M</au><au>Di Giorgio, Christophe</au><au>Vélaz, Itziar</au><au>Tros de Ilarduya, Concepción</au><au>Ortiz Mellet, Carmen</au><au>García Fernández, José M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2019-07-11</date><risdate>2019</risdate><volume>55</volume><issue>57</issue><spage>8227</spage><epage>823</epage><pages>8227-823</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery
in vitro
and
in vivo
.
Trehalose Siamese twin vectors, encompassing gemini and facial amphiphilicity, promote pDNA compaction into core-shell nanocomplexes and selective delivery in the lungs.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31268107</pmid><doi>10.1039/c9cc04489b</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-5249-9013</orcidid><orcidid>https://orcid.org/0000-0002-3183-3625</orcidid><orcidid>https://orcid.org/0000-0002-6827-0387</orcidid><orcidid>https://orcid.org/0000-0002-4391-2937</orcidid><orcidid>https://orcid.org/0000-0003-2728-9433</orcidid><orcidid>https://orcid.org/0000-0002-9788-1507</orcidid><orcidid>https://orcid.org/0000-0002-7676-7721</orcidid><orcidid>https://orcid.org/0000-0001-5230-6077</orcidid><orcidid>https://orcid.org/0000-0001-6414-2719</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2019-07, Vol.55 (57), p.8227-823 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Cell Line Cercopithecus aethiops Disaccharides Humans Mice Nanoparticles Nanostructures - chemistry NMR Nuclear magnetic resonance Plasmids Plasmids - chemistry Plasmids - metabolism Surface-Active Agents - chemistry Topology Transfection - methods Trehalose Trehalose - chemistry |
| title | Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties |
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