A supramolecular hydrogel prepared from a thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sm01383g

A supramolecular hydrogel prepared from a thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sm01383g

An artificial nucleolipid containing thymine, a triazole-ring, and phosphatidylcholine (TTPC) moieties was prepared by copper catalyzed azide alkyne cycloaddition (CuAAC) under aqueous conditions. The resulting TTPC molecules assembled in situ into a fibrous aggregation. The study of the TTPC fiber...

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Hauptverfasser: Zhang, Dawei, Liu, Qingkun, Visvanathan, Rayshan, Tuchband, Michael R, Sheetah, Ghadah H, Fairbanks, Benjamin D, Clark, Noel A, Smalyukh, Ivan I, Bowman, Christopher N
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container_title
container_volume 14
creator Zhang, Dawei
Liu, Qingkun
Visvanathan, Rayshan
Tuchband, Michael R
Sheetah, Ghadah H
Fairbanks, Benjamin D
Clark, Noel A
Smalyukh, Ivan I
Bowman, Christopher N
description An artificial nucleolipid containing thymine, a triazole-ring, and phosphatidylcholine (TTPC) moieties was prepared by copper catalyzed azide alkyne cycloaddition (CuAAC) under aqueous conditions. The resulting TTPC molecules assembled in situ into a fibrous aggregation. The study of the TTPC fiber assembly using XRD and NMR spectroscopy revealed that the formation of fibers was driven by the unique combination of the lipid and nucleobase moieties in the structure of TTPC. At a critical TTPC concentration, entanglement of the fibers resulted in the formation of a supramolecular hydrogel. Investigation of the lyotropic mesophases in the TTPC supramolecular hydrogel showed the presence of multiple phases including two liquid crystal phases ( i.e. , nematic and lamellar), which have a certain degree of structural order and are promising templates for constructing functional biomaterials. Study of assembly and lyotropic mesophases in a supramolecular hydrogel composed of a thymine-containing artificial nucleolipid (TTPC).
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title A supramolecular hydrogel prepared from a thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sm01383g
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