A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sc05612a
We report the synthesis of enantiomerically enriched 1,4-benzodioxanes containing alkyl, aryl, heteroaryl, and/or carbonyl substituents at the 2-position. The starting 1,4-benzodioxines were readily synthesized via ring closing metathesis using an efficient nitro-Grela catalyst at ppm levels. Excell...
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