Diverse secondary C(sp3)-H bond functionalization via site-selective trifluoroacetoxylation of aliphatic aminesElectronic supplementary information (ESI) available: Experimental details and compound characterization. See DOI: 10.1039/c8sc01788c

Diverse secondary C(sp3)-H bond functionalization via site-selective trifluoroacetoxylation of aliphatic aminesElectronic supplementary information (ESI) available: Experimental details and compound characterization. See DOI: 10.1039/c8sc01788c

We describe a coinage-metal-catalyzed site-selective oxidation of secondary C(sp 3 )-H bonds for aliphatic amine substrates. Broad amine scope, good functional compatibility and late-stage diversification are demonstrated with this method. The steric demand of the β-substituents controlled diastereo...

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Hauptverfasser: Tang, Yongzhen, Qin, Yuman, Meng, Dongmei, Li, Chaoqun, Wei, Junfa, Yang, Mingyu
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creator Tang, Yongzhen
Qin, Yuman
Meng, Dongmei
Li, Chaoqun
Wei, Junfa
Yang, Mingyu
description We describe a coinage-metal-catalyzed site-selective oxidation of secondary C(sp 3 )-H bonds for aliphatic amine substrates. Broad amine scope, good functional compatibility and late-stage diversification are demonstrated with this method. The steric demand of the β-substituents controlled diastereoselectivities under this catalytic system. The site selectivity favors secondary C(sp 3 )-H bonds over tertiary ones underscoring the unique synthetic potential of this method. A coinage-metal-catalyzed site-selective trifluoroacetoxylation of remote secondary C(sp 3 )-H bonds for aliphatic amine substrates was developed.
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title Diverse secondary C(sp3)-H bond functionalization via site-selective trifluoroacetoxylation of aliphatic aminesElectronic supplementary information (ESI) available: Experimental details and compound characterization. See DOI: 10.1039/c8sc01788c
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