Synthesis of cyano-substituted carbazoles successive C-C/C-H cleavage
A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs 2 CO 3 promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2019-01, Vol.17 (4), p.958-965 |
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| container_end_page | 965 |
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| container_issue | 4 |
| container_start_page | 958 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 17 |
| creator | Yang, Yajie Huang, Jiaqi Tan, Hailu Kong, Lingkai Wang, Mengdan Yuan, Yang Li, Yanzhong |
| description | A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs
2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp
2
C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.
Cs
2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations towards cyano carbazoles. |
| doi_str_mv | 10.1039/c8ob03031f |
| format | Article |
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2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp
2
C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.
Cs
2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations towards cyano carbazoles.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/c8ob03031f</identifier><ispartof>Organic & biomolecular chemistry, 2019-01, Vol.17 (4), p.958-965</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Yang, Yajie</creatorcontrib><creatorcontrib>Huang, Jiaqi</creatorcontrib><creatorcontrib>Tan, Hailu</creatorcontrib><creatorcontrib>Kong, Lingkai</creatorcontrib><creatorcontrib>Wang, Mengdan</creatorcontrib><creatorcontrib>Yuan, Yang</creatorcontrib><creatorcontrib>Li, Yanzhong</creatorcontrib><title>Synthesis of cyano-substituted carbazoles successive C-C/C-H cleavage</title><title>Organic & biomolecular chemistry</title><description>A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs
2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp
2
C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.
Cs
2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations towards cyano carbazoles.</description><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFjr0KwjAYAIMoWH8WdyEvEPvFVGvnUOmue0ljqpHaSL60UJ_eRXR0uoNbjpAVhw0HkcX64CoQIHg9IhFP0pTBTmTjr29hSmaIdwCepfskIvlpaMPNoEXqaqoH1TqGXYXBhi6YC9XKV-rlGoMUO60Nou0NlUzGkhVUN0b16moWZFKrBs3ywzlZH_OzLJhHXT69fSg_lL838a-_ARYbPJA</recordid><startdate>20190123</startdate><enddate>20190123</enddate><creator>Yang, Yajie</creator><creator>Huang, Jiaqi</creator><creator>Tan, Hailu</creator><creator>Kong, Lingkai</creator><creator>Wang, Mengdan</creator><creator>Yuan, Yang</creator><creator>Li, Yanzhong</creator><scope/></search><sort><creationdate>20190123</creationdate><title>Synthesis of cyano-substituted carbazoles successive C-C/C-H cleavage</title><author>Yang, Yajie ; Huang, Jiaqi ; Tan, Hailu ; Kong, Lingkai ; Wang, Mengdan ; Yuan, Yang ; Li, Yanzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c8ob03031f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yajie</creatorcontrib><creatorcontrib>Huang, Jiaqi</creatorcontrib><creatorcontrib>Tan, Hailu</creatorcontrib><creatorcontrib>Kong, Lingkai</creatorcontrib><creatorcontrib>Wang, Mengdan</creatorcontrib><creatorcontrib>Yuan, Yang</creatorcontrib><creatorcontrib>Li, Yanzhong</creatorcontrib><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yajie</au><au>Huang, Jiaqi</au><au>Tan, Hailu</au><au>Kong, Lingkai</au><au>Wang, Mengdan</au><au>Yuan, Yang</au><au>Li, Yanzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of cyano-substituted carbazoles successive C-C/C-H cleavage</atitle><jtitle>Organic & biomolecular chemistry</jtitle><date>2019-01-23</date><risdate>2019</risdate><volume>17</volume><issue>4</issue><spage>958</spage><epage>965</epage><pages>958-965</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs
2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp
2
C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.
Cs
2
CO
3
promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations towards cyano carbazoles.</abstract><doi>10.1039/c8ob03031f</doi><tpages>8</tpages></addata></record> |
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| ispartof | Organic & biomolecular chemistry, 2019-01, Vol.17 (4), p.958-965 |
| issn | 1477-0520 1477-0539 |
| language | |
| recordid | cdi_rsc_primary_c8ob03031f |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Synthesis of cyano-substituted carbazoles successive C-C/C-H cleavage |
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