Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-]pyridines
A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Prelim...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2018-09, Vol.16 (35), p.643-6437 |
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| container_end_page | 6437 |
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| container_issue | 35 |
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| container_title | Organic & biomolecular chemistry |
| container_volume | 16 |
| creator | Nitha, P. R Joseph, Manu M Gopalan, Greeshma Maiti, Kaustabh Kumar Radhakrishnan, K. V Das, Parthasarathi |
| description | A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biological evaluation of cytotoxicity on selected examples provides scope for future investigations.
A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically active 2-amidoimidazopyridine scaffolds. |
| doi_str_mv | 10.1039/c8ob01486h |
| format | Article |
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A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically active 2-amidoimidazopyridine scaffolds.</description><subject>Amines</subject><subject>Carbon monoxide</subject><subject>Chemical synthesis</subject><subject>Chloroform</subject><subject>Cytotoxicity</subject><subject>Palladium</subject><subject>Pyridines</subject><subject>Toxicity</subject><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkU1Lw0AQhhdRbK1evCsLXkSM7kc2mxy1qBUKvehJJGz2g25JsnU3Adtf72prBS8zA_Mw8847AJxidIMRLW5l7iqE0zyb74EhTjlPEKPF_q4maACOQlgghAuepYdgQBGmhPNiCObjee28M843UAQooBS-ci1sXOs-rdIwuN5LDW0Ll6KuhbJ9k0jRiXq11gqGVdvNdbABOgNJIhqrnI1BrN0bvibJ-3LlrbKtDsfgwIg66JNtHoHXx4eX8SSZzp6ex3fTRFLKu8QIxipT5VIKprIccZXHqA2rGGFYGJxxxbKUEl1hwXPOuKqMzDKtUxxrSkfgcjN36d1Hr0NXNjZIHaW32vWhJKjAOWYoLSJ68Q9dxGPbqK4kGJG4hESfRuBqQ0nvQvDalEtvG-FXJUblt__lOJ_d__g_ifD5dmRfNVrt0F_DI3C2AXyQu-7fA-kXznuKbA</recordid><startdate>20180911</startdate><enddate>20180911</enddate><creator>Nitha, P. R</creator><creator>Joseph, Manu M</creator><creator>Gopalan, Greeshma</creator><creator>Maiti, Kaustabh Kumar</creator><creator>Radhakrishnan, K. V</creator><creator>Das, Parthasarathi</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8909-3175</orcidid><orcidid>https://orcid.org/0000-0002-9306-4956</orcidid><orcidid>https://orcid.org/0000-0003-3368-6929</orcidid></search><sort><creationdate>20180911</creationdate><title>Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-]pyridines</title><author>Nitha, P. R ; Joseph, Manu M ; Gopalan, Greeshma ; Maiti, Kaustabh Kumar ; Radhakrishnan, K. V ; Das, Parthasarathi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-fa55bfb8cca5d6807d8680ef5b5251af167d56432eb1a78757dbfc66ee4157d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amines</topic><topic>Carbon monoxide</topic><topic>Chemical synthesis</topic><topic>Chloroform</topic><topic>Cytotoxicity</topic><topic>Palladium</topic><topic>Pyridines</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nitha, P. R</creatorcontrib><creatorcontrib>Joseph, Manu M</creatorcontrib><creatorcontrib>Gopalan, Greeshma</creatorcontrib><creatorcontrib>Maiti, Kaustabh Kumar</creatorcontrib><creatorcontrib>Radhakrishnan, K. V</creatorcontrib><creatorcontrib>Das, Parthasarathi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nitha, P. R</au><au>Joseph, Manu M</au><au>Gopalan, Greeshma</au><au>Maiti, Kaustabh Kumar</au><au>Radhakrishnan, K. V</au><au>Das, Parthasarathi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-]pyridines</atitle><jtitle>Organic & biomolecular chemistry</jtitle><addtitle>Org Biomol Chem</addtitle><date>2018-09-11</date><risdate>2018</risdate><volume>16</volume><issue>35</issue><spage>643</spage><epage>6437</epage><pages>643-6437</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biological evaluation of cytotoxicity on selected examples provides scope for future investigations.
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| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2018-09, Vol.16 (35), p.643-6437 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_rsc_primary_c8ob01486h |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amines Carbon monoxide Chemical synthesis Chloroform Cytotoxicity Palladium Pyridines Toxicity |
| title | Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-]pyridines |
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