Direct oxidative C-H alkynylation of -carbamoyl tetrahydroisoquinolines and dihydroisoquinolines
An efficient oxidative C-H alkynylation of N -carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied N -carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2018-04, Vol.16 (15), p.2792-2799 |
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| container_issue | 15 |
| container_start_page | 2792 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 16 |
| creator | Chen, Lei Sun, Chuanxi Feng, Guidong Cao, Min Zhao, Shu-lei Yan, Jun Wan, Ren-zhong Liu, Lei |
| description | An efficient oxidative C-H alkynylation of
N
-carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied
N
-carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free conditions. Dihydroisoquinolines were also suitable components for the reaction. The synthetic applicability of the method for facile access to structurally diverse bioactive molecules was further demonstrated.
An efficient oxidative C-H alkynylation of
N
-carbamoyl tetrahydroisoquinolines and dihydroisoquinolines is described. |
| doi_str_mv | 10.1039/c8ob00373d |
| format | Article |
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N
-carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied
N
-carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free conditions. Dihydroisoquinolines were also suitable components for the reaction. The synthetic applicability of the method for facile access to structurally diverse bioactive molecules was further demonstrated.
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N
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N
-carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied
N
-carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free conditions. Dihydroisoquinolines were also suitable components for the reaction. The synthetic applicability of the method for facile access to structurally diverse bioactive molecules was further demonstrated.
An efficient oxidative C-H alkynylation of
N
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N
-carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied
N
-carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free conditions. Dihydroisoquinolines were also suitable components for the reaction. The synthetic applicability of the method for facile access to structurally diverse bioactive molecules was further demonstrated.
An efficient oxidative C-H alkynylation of
N
-carbamoyl tetrahydroisoquinolines and dihydroisoquinolines is described.</abstract><doi>10.1039/c8ob00373d</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2018-04, Vol.16 (15), p.2792-2799 |
| issn | 1477-0520 1477-0539 |
| language | |
| recordid | cdi_rsc_primary_c8ob00373d |
| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| title | Direct oxidative C-H alkynylation of -carbamoyl tetrahydroisoquinolines and dihydroisoquinolines |
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