Dual-receptor targeted strategy in nanoparticle design achieves tumor cell selectivity through cooperativity

Targeted liposomal nanoparticles are commonly used drug delivery vehicles for targeting cancer cells that overexpress a particular cell surface receptor. However, typical target receptors are also expressed at variable levels in healthy tissue, leading to non-selective targeting and systemic toxicit...

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Veröffentlicht in:Nanoscale 2019-03, Vol.11 (1), p.4414-4427
Hauptverfasser: Stefanick, Jared Francis, Omstead, David Thomas, Kiziltepe, Tanyel, Bilgicer, Basar
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Sprache:eng
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