New reactions and processes for the efficient synthesis of a HCV NS5b prodrug

Herein we describe the route scouting and process development efforts toward a green and sustainable synthesis of the HCV NS5b cyclic prodrug nucleoside (CPN) 1 . Through the discovery and development of a crystallization-induced dynamic resolution and a novel chemo- and stereo-selective phosphoryla...

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Veröffentlicht in:	Green chemistry : an international journal and green chemistry resource : GC 2018, Vol.2 (11), p.2519-2525
Hauptverfasser:	Orr, Robert K, McCabe Dunn, Jamie M, Nolting, Andrew, Hyde, Alan M, Ashley, Eric R, Leone, Joseph, Sirota, Eric, Jurica, Jon A, Gibson, Andrew, Wise, Christopher, Oliver, Steven, Ruck, Rebecca T
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical synthesis Crystallization Green chemistry Molecular chains Phosphorylation RNA-directed RNA polymerase Sustainable development
Online-Zugang:	Volltext
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