Adverse reproductive performance in zebrafish with increased bioconcentration of microcystin-LR in the presence of titanium dioxide nanoparticlesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8en00174j
The aim of the present study was to investigate the reproductive effects of microcystin-LR (MCLR) in the presence of titanium dioxide nanoparticles (n-TiO 2 ). Five-month-old zebrafish were exposed to MCLR (0, 0.5, 4 and 32 μg L −1 ) alone or combined with n-TiO 2 (100 μg L −1 ) for 21 days. The acc...
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| creator | Cheng, Houcheng Yan, Wei Wu, Qin Lu, Juanli Liu, Chunsheng Hung, Tien-Chieh Li, Guangyu |
| description | The aim of the present study was to investigate the reproductive effects of microcystin-LR (MCLR) in the presence of titanium dioxide nanoparticles (n-TiO
2
). Five-month-old zebrafish were exposed to MCLR (0, 0.5, 4 and 32 μg L
−1
) alone or combined with n-TiO
2
(100 μg L
−1
) for 21 days. The accumulation of both n-TiO
2
and MCLR was observed in the fish liver, brain and gonad. Enhanced bioconcentration of MCLR was measured in coexposure groups. Joint exposure to both n-TiO
2
and MCLR significantly reduced the fecundity of adult fish compared to the MCLR-only treatment. Histopathological examination revealed no obvious change in the morphology of the ovary and testis, while a significant decline of estradiol (E2) and testosterone (T) levels as well as disordered transcription patterns of genes along the hypothalamus-pituitary-gonadal (HPG) axis was observed. N-TiO
2
may act as a carrier of MCLR and increase its concentration upon coming in contact with zebrafish, which exacerbated the reproductive endocrine dysfunction as a consequence.
The aim of the present study was to investigate the reproductive effects of microcystin-LR (MCLR) in the presence of titanium dioxide nanoparticles (n-TiO
2
). |
| doi_str_mv | 10.1039/c8en00174j |
| format | Article |
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2
). Five-month-old zebrafish were exposed to MCLR (0, 0.5, 4 and 32 μg L
−1
) alone or combined with n-TiO
2
(100 μg L
−1
) for 21 days. The accumulation of both n-TiO
2
and MCLR was observed in the fish liver, brain and gonad. Enhanced bioconcentration of MCLR was measured in coexposure groups. Joint exposure to both n-TiO
2
and MCLR significantly reduced the fecundity of adult fish compared to the MCLR-only treatment. Histopathological examination revealed no obvious change in the morphology of the ovary and testis, while a significant decline of estradiol (E2) and testosterone (T) levels as well as disordered transcription patterns of genes along the hypothalamus-pituitary-gonadal (HPG) axis was observed. N-TiO
2
may act as a carrier of MCLR and increase its concentration upon coming in contact with zebrafish, which exacerbated the reproductive endocrine dysfunction as a consequence.
The aim of the present study was to investigate the reproductive effects of microcystin-LR (MCLR) in the presence of titanium dioxide nanoparticles (n-TiO
2
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2
). Five-month-old zebrafish were exposed to MCLR (0, 0.5, 4 and 32 μg L
−1
) alone or combined with n-TiO
2
(100 μg L
−1
) for 21 days. The accumulation of both n-TiO
2
and MCLR was observed in the fish liver, brain and gonad. Enhanced bioconcentration of MCLR was measured in coexposure groups. Joint exposure to both n-TiO
2
and MCLR significantly reduced the fecundity of adult fish compared to the MCLR-only treatment. Histopathological examination revealed no obvious change in the morphology of the ovary and testis, while a significant decline of estradiol (E2) and testosterone (T) levels as well as disordered transcription patterns of genes along the hypothalamus-pituitary-gonadal (HPG) axis was observed. N-TiO
2
may act as a carrier of MCLR and increase its concentration upon coming in contact with zebrafish, which exacerbated the reproductive endocrine dysfunction as a consequence.
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2
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2
). Five-month-old zebrafish were exposed to MCLR (0, 0.5, 4 and 32 μg L
−1
) alone or combined with n-TiO
2
(100 μg L
−1
) for 21 days. The accumulation of both n-TiO
2
and MCLR was observed in the fish liver, brain and gonad. Enhanced bioconcentration of MCLR was measured in coexposure groups. Joint exposure to both n-TiO
2
and MCLR significantly reduced the fecundity of adult fish compared to the MCLR-only treatment. Histopathological examination revealed no obvious change in the morphology of the ovary and testis, while a significant decline of estradiol (E2) and testosterone (T) levels as well as disordered transcription patterns of genes along the hypothalamus-pituitary-gonadal (HPG) axis was observed. N-TiO
2
may act as a carrier of MCLR and increase its concentration upon coming in contact with zebrafish, which exacerbated the reproductive endocrine dysfunction as a consequence.
The aim of the present study was to investigate the reproductive effects of microcystin-LR (MCLR) in the presence of titanium dioxide nanoparticles (n-TiO
2
).</abstract><doi>10.1039/c8en00174j</doi><tpages>1</tpages></addata></record> |
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| title | Adverse reproductive performance in zebrafish with increased bioconcentration of microcystin-LR in the presence of titanium dioxide nanoparticlesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8en00174j |
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