Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisationElectronic supplementary information (ESI) available. CCDC 1867837. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8ce01720d

Herein, we report a new polymorph of amodiaquine dihydrochloride dihydrate obtained via heterogeneous crystallisation. This new polymorph exhibits similarity in molecular conformation as well as in its one-dimensional chain structure with a previously known polymorph, however with a difference in its two-dimensional sheet structure. Although crystal DFT-calculations predict the new form to be thermodynamically less stable compared to the previously known polymorph, the preparation method applied opened up the access to its metastable zone. A new polymorph of amodiaquine dihydrochloride dihydrate was obtained via heterogenous crystallization. This new polymorph showed difference in two-dimensional sheet structure compare to previously known polymorph.