Expedient Diels-Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactorElectronic supplementary information (ESI) available: Optimization study details, experimental procedures, characterization data, copies of 1H, 13C and 2D NMR spectra. See DOI: 10.1039/c7re00058h
We describe herein Diels-Alder cycloadditions enabled by the efficient ring-opening of benzocyclobutenes and benzothiophene-2,2-dioxides using a high temperature/pressure flow reactor. The resultant ortho -quinodimethanes were generated and subsequently reacted with a wide range of dienophiles to pr...
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