Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegansElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra09100a
Graphene oxide (GO) induces some dysregulated microRNAs (miRNAs), such as mir-247 , in Caenorhabditis elegans . We here further investigated the role and value of mir-247 in detecting GO toxicity in nematodes after prolonged exposure. In nematodes, mir-247 acted in neurons to regulate GO toxicity, a...
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| creator | Xiao, Guosheng Zhi, Lingtong Ding, Xuecheng Rui, Qi Wang, Dayong |
| description | Graphene oxide (GO) induces some dysregulated microRNAs (miRNAs), such as
mir-247
, in
Caenorhabditis elegans
. We here further investigated the role and value of
mir-247
in detecting GO toxicity in nematodes after prolonged exposure. In nematodes,
mir-247
acted in neurons to regulate GO toxicity, and neuronal overexpression of
mir-247
induced a susceptibility to GO toxicity. We detected the significant increase in
mir-247
in wild-type nematodes exposed to GO at concentrations of more than 10 μg L
−1
. Moreover, we found the GO toxicity in a transgenic strain overexpressing neuronal
mir-247
after exposure to GO at concentrations of more than 10 μg L
−1
. Therefore, our results imply the important potential of
mir-247
in warning of the formation of GO toxicity in the range of μg L
−1
in nematodes.
Our results imply the important potential of
mir-247
in warning the formation of GO toxicity in the range of μg L
−1
in nematodes. |
| doi_str_mv | 10.1039/c7ra09100a |
| format | Article |
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mir-247
, in
Caenorhabditis elegans
. We here further investigated the role and value of
mir-247
in detecting GO toxicity in nematodes after prolonged exposure. In nematodes,
mir-247
acted in neurons to regulate GO toxicity, and neuronal overexpression of
mir-247
induced a susceptibility to GO toxicity. We detected the significant increase in
mir-247
in wild-type nematodes exposed to GO at concentrations of more than 10 μg L
−1
. Moreover, we found the GO toxicity in a transgenic strain overexpressing neuronal
mir-247
after exposure to GO at concentrations of more than 10 μg L
−1
. Therefore, our results imply the important potential of
mir-247
in warning of the formation of GO toxicity in the range of μg L
−1
in nematodes.
Our results imply the important potential of
mir-247
in warning the formation of GO toxicity in the range of μg L
−1
in nematodes.</description><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c7ra09100a</identifier><language>eng</language><creationdate>2017-11</creationdate><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Xiao, Guosheng</creatorcontrib><creatorcontrib>Zhi, Lingtong</creatorcontrib><creatorcontrib>Ding, Xuecheng</creatorcontrib><creatorcontrib>Rui, Qi</creatorcontrib><creatorcontrib>Wang, Dayong</creatorcontrib><title>Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegansElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra09100a</title><description>Graphene oxide (GO) induces some dysregulated microRNAs (miRNAs), such as
mir-247
, in
Caenorhabditis elegans
. We here further investigated the role and value of
mir-247
in detecting GO toxicity in nematodes after prolonged exposure. In nematodes,
mir-247
acted in neurons to regulate GO toxicity, and neuronal overexpression of
mir-247
induced a susceptibility to GO toxicity. We detected the significant increase in
mir-247
in wild-type nematodes exposed to GO at concentrations of more than 10 μg L
−1
. Moreover, we found the GO toxicity in a transgenic strain overexpressing neuronal
mir-247
after exposure to GO at concentrations of more than 10 μg L
−1
. Therefore, our results imply the important potential of
mir-247
in warning of the formation of GO toxicity in the range of μg L
−1
in nematodes.
Our results imply the important potential of
mir-247
in warning the formation of GO toxicity in the range of μg L
−1
in nematodes.</description><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFj09Lw0AQxRdBsGgv3oXxpoe0u0lNidcaaU8eWryGaTJJRza7YXfrn6_kp3QDggdB5_Lgvd8beEJcKjlTMivm9dKhLJSUeCImqVzkSSrz4kxMvX-R8fI7leZqIj6fUR8JbAs9uyRdLIENvKEzbLrR7RwOBzKReOeGIESpOXyMlKEeg43mCslYd8B9w4E9kKYOjS811cFZwzX44zBo6skEdGO1tS5W2Rq4KbebW8BXZI17TTPYEsHD0-Yefg-5EKctak_Tbz0XV4_lbrVOnK-rwXEfn1c_ePZ_fv1XXg1Nm30BngNooQ</recordid><startdate>20171114</startdate><enddate>20171114</enddate><creator>Xiao, Guosheng</creator><creator>Zhi, Lingtong</creator><creator>Ding, Xuecheng</creator><creator>Rui, Qi</creator><creator>Wang, Dayong</creator><scope/></search><sort><creationdate>20171114</creationdate><title>Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegansElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra09100a</title><author>Xiao, Guosheng ; Zhi, Lingtong ; Ding, Xuecheng ; Rui, Qi ; Wang, Dayong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c7ra09100a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Guosheng</creatorcontrib><creatorcontrib>Zhi, Lingtong</creatorcontrib><creatorcontrib>Ding, Xuecheng</creatorcontrib><creatorcontrib>Rui, Qi</creatorcontrib><creatorcontrib>Wang, Dayong</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Guosheng</au><au>Zhi, Lingtong</au><au>Ding, Xuecheng</au><au>Rui, Qi</au><au>Wang, Dayong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegansElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra09100a</atitle><date>2017-11-14</date><risdate>2017</risdate><volume>7</volume><issue>83</issue><spage>52694</spage><epage>5271</epage><pages>52694-5271</pages><eissn>2046-2069</eissn><abstract>Graphene oxide (GO) induces some dysregulated microRNAs (miRNAs), such as
mir-247
, in
Caenorhabditis elegans
. We here further investigated the role and value of
mir-247
in detecting GO toxicity in nematodes after prolonged exposure. In nematodes,
mir-247
acted in neurons to regulate GO toxicity, and neuronal overexpression of
mir-247
induced a susceptibility to GO toxicity. We detected the significant increase in
mir-247
in wild-type nematodes exposed to GO at concentrations of more than 10 μg L
−1
. Moreover, we found the GO toxicity in a transgenic strain overexpressing neuronal
mir-247
after exposure to GO at concentrations of more than 10 μg L
−1
. Therefore, our results imply the important potential of
mir-247
in warning of the formation of GO toxicity in the range of μg L
−1
in nematodes.
Our results imply the important potential of
mir-247
in warning the formation of GO toxicity in the range of μg L
−1
in nematodes.</abstract><doi>10.1039/c7ra09100a</doi><tpages>8</tpages></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegansElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra09100a |
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