Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimicsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7py01133d
We investigated intra-chain isocyanide-based multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each junction point in order to create materials featuring multiple protein-inspired elements. Upon intramolecular cross-linking, nanoparticle...
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| creator | Cole, J. P Lessard, J. J Rodriguez, K. J Hanlon, A. M Reville, E. K Mancinelli, J. P Berda, E. B |
| description | We investigated intra-chain isocyanide-based multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each junction point in order to create materials featuring multiple protein-inspired elements. Upon intramolecular cross-linking, nanoparticle formation ensues, affording materials with well-defined structural elements situated in a disordered tertiary structure. The resulting nanostructures were characterized using
1
H NMR, DOSY NMR, and size-exclusion chromatography. While covalent cross-linking was the intended and predominant mode of SCNP formation, we found that secondary, noncovalent interactions contributed significantly to nanoparticle folding more akin to natural materials.
We investigated intra-chain multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each cross-link, creating materials featuring multiple protein-inspired elements. |
| doi_str_mv | 10.1039/c7py01133d |
| format | Article |
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1
H NMR, DOSY NMR, and size-exclusion chromatography. While covalent cross-linking was the intended and predominant mode of SCNP formation, we found that secondary, noncovalent interactions contributed significantly to nanoparticle folding more akin to natural materials.
We investigated intra-chain multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each cross-link, creating materials featuring multiple protein-inspired elements.</description><identifier>ISSN: 1759-9954</identifier><identifier>EISSN: 1759-9962</identifier><identifier>DOI: 10.1039/c7py01133d</identifier><language>eng</language><creationdate>2017-10</creationdate><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Cole, J. P</creatorcontrib><creatorcontrib>Lessard, J. J</creatorcontrib><creatorcontrib>Rodriguez, K. J</creatorcontrib><creatorcontrib>Hanlon, A. M</creatorcontrib><creatorcontrib>Reville, E. K</creatorcontrib><creatorcontrib>Mancinelli, J. P</creatorcontrib><creatorcontrib>Berda, E. B</creatorcontrib><title>Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimicsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7py01133d</title><description>We investigated intra-chain isocyanide-based multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each junction point in order to create materials featuring multiple protein-inspired elements. Upon intramolecular cross-linking, nanoparticle formation ensues, affording materials with well-defined structural elements situated in a disordered tertiary structure. The resulting nanostructures were characterized using
1
H NMR, DOSY NMR, and size-exclusion chromatography. While covalent cross-linking was the intended and predominant mode of SCNP formation, we found that secondary, noncovalent interactions contributed significantly to nanoparticle folding more akin to natural materials.
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1
H NMR, DOSY NMR, and size-exclusion chromatography. While covalent cross-linking was the intended and predominant mode of SCNP formation, we found that secondary, noncovalent interactions contributed significantly to nanoparticle folding more akin to natural materials.
We investigated intra-chain multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each cross-link, creating materials featuring multiple protein-inspired elements.</abstract><doi>10.1039/c7py01133d</doi><tpages>7</tpages></addata></record> |
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| title | Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimicsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7py01133d |
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