Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivativesElectronic supplementary information (ESI) available: Experimental procedures and data for all new compounds including traces of chiral SFC. See DOI: 10.1039/c7ob02578e

A new efficient chiral synthesis of enantiopure arimoclomol ( 2 ) is reported from ( R )-(−)-glycidyl nosylate ( 11 ) with complete retention of chiral integrity. Off-target pharmacology of arimoclomol ( 2 ) was evaluated against a representative set of drug targets and showed modest binding to a fe...

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Hauptverfasser:	Atkinson, Benjamin N, Woodward, Hannah L, Sipthorp, James, Fish, Paul V
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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