Novel pyrrolobenzodiazepine and pyrroloquinazoline scaffolds synthesized by a simple and highly selective Ugi/cyclization sequenceElectronic supplementary information (ESI) available. CCDC 1553094-1553095. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ob01807j

Pyrrolo[2,1- c ][1,4]benzodiazepines (PBDs) and other benzo-fused N-heterocycles constitute privileged structures found in numerous bioactive compounds. Thus, developing simple and selective syntheses to furnish these derivatives from easily accessible starting materials is an important and challeng...

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Hauptverfasser: Pertejo, Pablo, Peña-Calleja, Pablo, Carreira-Barral, Israel, Quesada, Roberto, Alejandro Cordero, Nicolás, Javier Rodríguez, Francisco, García-Valverde, María
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Sprache:eng
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