Triflic acid-catalyzed metal-free synthesis of (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-dionesElectronic supplementary information (ESI) available. See DOI: 10.1039/c7nj05169g
A TfOH-catalyzed highly efficient synthesis of biologically active ( E )-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones has been reported with 64-94% yields under metal-free conditions. The reaction proceeds through sequential Knoevenagel condensation/stereoselective in situ monohydration...
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