Cyclometalated ruthenium complexes from naturally occurring quinones: studies on their photophysical features, computational details and trypanocidal activityElectronic supplementary information (ESI) available. CCDC 1477601. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7nj00379j

Phenazinic ligands and Ru( ii )-based complexes were synthesized from natural products lapachol and lawsone and evaluated against T. cruzi , the etiological agent of Chagas disease. These new ruthenium compounds could provide promising trypanocidal drugs. Besides synthesis and trypanocidal activity, this paper reports photophysical features and computational details of the compounds. The fluorescent trypanocidal substances are promising derivatives for further studies aiming to find molecules active against parasites associated with neglected diseases. Ligands and Ru( ii )-based complexes were synthesized from natural products and evaluated against T. cruzi . These compounds could provide promising trypanocidal drugs.