Synthesis, structure-activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenaseThe authors declare no competing interests.Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00081b

A series of 4-thiazolidinone derivatives were synthesized and evaluated as novel human dihydroorotate dehydrogenase ( h DHODH) inhibitors. Compounds 26 and 31 displayed IC 50 values of 1.75 and 1.12 μM, respectively. The structure-activity relationship was summarized. Further binding mode analysis r...

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Hauptverfasser:	Zeng, Fanxun, Qi, Tiantian, Li, Chunyan, Li, Tingfang, Li, Honglin, Li, Shiliang, Zhu, Lili, Xu, Xiaoyong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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