Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acidsElectronic supplementary information (ESI) available: Experimental procedures, further optimization data and characterization of all compounds. See DOI: 10.1039/c7gc02913f

Fluoroform (CHF 3 ) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity of fluoroform, only very few applications have been reported so far. Herein we report a continuous flow difluoromethylation protocol on sp 3 carbons employing fluoroform as...

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Hauptverfasser:	Köckinger, Manuel, Ciaglia, Tanja, Bersier, Michael, Hanselmann, Paul, Gutmann, Bernhard, Kappe, C. Oliver
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